FB2025_01 , released February 20, 2025
Allele: Dmel\ykiM123.UAS.Tag:MYC
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General Information
Symbol
Dmel\ykiM123.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0239898
Feature type
allele
Associated gene
Dmel\yki
Associated Insertion(s)
Carried in Construct
P{UAS-yki.M123.Myc}
Key Links
Transgenic product class
missense_variant
(Zhang et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Zhang et al., 2008)
Mutagen
in vitro construct
(Zhang et al., 2008)
Progenitor genotype
ykiUAS.Tag:MYC
(Zhang et al., 2008)
Carried in construct
P{UAS-yki.M123.Myc}
Cytology
Description

UAS regulatory sequences drive expression of a mutated form of yki that carries the amino acid replacements S168A, S169A and S172A. The protein is tagged with Tag:MYC.

(Zhang et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
yki
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of ykiM123.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4ptc-559.1 leads to a hyperplastic overgrowth of the (ptc-positive) domain of expression at the anterior-posterior compartment boundary of the third instar larval wing disc, as compared to controls.

      (Tamori et al., 2016)

      Expression of ykiM123.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PF results in overgrowth of the eye.

      Clones in the eye expressing ykiM123.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4tub result in an eye overgrowth phenotype.

      (Zhang et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Scer\GAL4Tub.PU, ykiM123.UAS.Tag:MYC has visible | somatic clone phenotype, suppressible | somatic clone by sdΔB

      (Zhang et al., 2008)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Scer\GAL4Tub.PU, ykiM123.UAS.Tag:MYC has eye | somatic clone phenotype, suppressible | somatic clone by sdΔB

      (Zhang et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The eye overgrowth phenotype caused by clones expressing ykiM123.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4tub is suppressed if the clones are also homozygous for sdΔB.

      (Zhang et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ykiCA
      (Tamori et al., 2016)
      ykiM123.Scer\UAS.T:Hsap\MYC
      ykiM123.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (4)