FlyBase Allele Report: Dmel\dock[JF02810]

General Information

Symbol

Dmel\dock^JF02810

Species

D. melanogaster

Name

FlyBase ID

FBal0242390

Feature type

allele

Associated gene

Dmel\dock

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02810}

Also Known As

UAS-Dock^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02810}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02810

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^eve.RN2

(Kamiyama et al., 2015)

abnormal neuroanatomy | larval stage, with Scer\GAL4^P2.4.Pdf

(Liu et al., 2024)

increased cell number | somatic clone, with Scer\GAL4^wor.PA

(de Torres-Jurado et al., 2022)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of dock^JF02810 under the control of Scer\GAL4^eve.RN2 results in defects in dendritogenesis in the embryonic aCC motoneurons (decreased number of dendritic tips, misplacement of primary branches) compared to controls.

(Kamiyama et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^eve.RN2, dock^JF02810 has abnormal neuroanatomy | embryonic stage phenotype, suppressible | partially by Pak^{UAS.Tag:Myr(Src64B)}, Scer\GAL4^eve.RN2

(Kamiyama et al., 2015)

NOT suppressed by

Statement

Reference

Scer\GAL4^eve.RN2, dock^JF02810 has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by Pak^UAS.mEos2, Scer\GAL4^eve.RN2

(Kamiyama et al., 2015)

Scer\GAL4^eve.RN2, dock^JF02810 has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by Cdc42⁴/Pak^{UAS.Tag:Myr(Src64B)}, Scer\GAL4^eve.RN2

(Kamiyama et al., 2015)

Scer\GAL4^eve.RN2, dock^JF02810 has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by Cdc42⁶/Pak^{UAS.Tag:Myr(Src64B)}, Scer\GAL4^eve.RN2

(Kamiyama et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^eve.RN2, dock^JF02810 has larval DA1 motor neuron | embryonic stage phenotype, suppressible | partially by Pak^{UAS.Tag:Myr(Src64B)}, Scer\GAL4^eve.RN2

(Kamiyama et al., 2015)

Scer\GAL4^eve.RN2, dock^JF02810 has dendrite | embryonic stage phenotype, suppressible | partially by Pak^{UAS.Tag:Myr(Src64B)}, Scer\GAL4^eve.RN2

(Kamiyama et al., 2015)

NOT suppressed by

Statement

Reference

Scer\GAL4^eve.RN2, dock^JF02810 has larval DA1 motor neuron | embryonic stage phenotype, non-suppressible by Pak^UAS.mEos2, Scer\GAL4^eve.RN2

(Kamiyama et al., 2015)

Scer\GAL4^eve.RN2, dock^JF02810 has dendrite | embryonic stage phenotype, non-suppressible by Pak^UAS.mEos2, Scer\GAL4^eve.RN2

(Kamiyama et al., 2015)

Scer\GAL4^eve.RN2, dock^JF02810 has larval DA1 motor neuron | embryonic stage phenotype, non-suppressible by Cdc42⁴/Pak^{UAS.Tag:Myr(Src64B)}, Scer\GAL4^eve.RN2

(Kamiyama et al., 2015)

Scer\GAL4^eve.RN2, dock^JF02810 has dendrite | embryonic stage phenotype, non-suppressible by Cdc42⁴/Pak^{UAS.Tag:Myr(Src64B)}, Scer\GAL4^eve.RN2

(Kamiyama et al., 2015)

Scer\GAL4^eve.RN2, dock^JF02810 has larval DA1 motor neuron | embryonic stage phenotype, non-suppressible by Cdc42⁶/Pak^{UAS.Tag:Myr(Src64B)}, Scer\GAL4^eve.RN2

(Kamiyama et al., 2015)

Scer\GAL4^eve.RN2, dock^JF02810 has dendrite | embryonic stage phenotype, non-suppressible by Cdc42⁶/Pak^{UAS.Tag:Myr(Src64B)}, Scer\GAL4^eve.RN2

(Kamiyama et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The dendritogenesis defects in the embryonic aCC motoneurons characteristic for embryos expressing dock^JF02810 RNAi under the control of Scer\GAL4^eve.RN2 are partially suppressed by co-expression of Pak^{Scer\UAS.T:Myr-Src64B} : the reduced dendritic number is fully restored but the region containing primary dendritic processes is expanded compared to controls. This rescue effect is however blocked in the presence of either Cdc42⁶ or Cdc42⁴ (in hemizygous state). No suppression of the loss of dendritic tips is observed upon co-expression with Pak^{Scer\UAS.T:Lhem\EosFP-m2}.

(Kamiyama et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27728

y¹ v¹; P{TRiP.JF02810}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dock^JF02810

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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