FlyBase Allele Report: Dmel\tor[HMS00021]

General Information

Symbol

Dmel\tor^HMS00021

Species

D. melanogaster

Name

FlyBase ID

FBal0257068

Feature type

allele

Associated gene

Dmel\tor

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00021}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00021}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00021

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate, with Scer\GAL4^phtm.PO

(Pan and O'Connor, 2021)

abnormal immune response | adult stage, with Scer\GAL4^NP0001

(Socha et al., 2023)

decreased rate of copulation | female, with Hsap\RELA^AD.VT002064, Scer\GAL4^{dsx-GAL4(DBD)::Zip-}

(Li et al., 2024)

decreased rate of movement | adult stage, with Scer\GAL4^elav.PU

(Yu et al., 2016)

female sterile, with Scer\GAL4^{VP16.mat.αTub67C}

(Sopko et al., 2014)

Phenotype Manifest In

adult enterocyte | conditional, with Scer\GAL4^NP0001

(Socha et al., 2023)

embryo | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Sopko et al., 2014)

Detailed Description

Statement

Reference

Expression of tor^HMS00021 under the control of Scer\GAL4^elav.PU in adult females significantly decreases locomotor activity in fed conditions, compared to controls; like controls, locomotor activity is significantly increased under starvation conditions.

(Yu et al., 2016)

Females heterozygous for tor^HMS00021 and Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} crossed to tor^HMS00021 males results in: 0% hatching; egg/embryonic phenotype: terminal class phenotype; maternal effect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

tor^HMS00021/Scer\GAL4^{VP16.mat.αTub67C} is a suppressor of decreased cell number | recessive | embryonic stage phenotype of gcl^rev390

(Pae et al., 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

tor^HMS00021/Scer\GAL4^{VP16.mat.αTub67C} is a suppressor of germline cell | embryonic stage phenotype of gcl^rev390

(Pae et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The expression of tor^HMS00021 under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} fully suppresses the decreased primordial germ cells in gcl^rev390 homozygous early embryos (i.e. mitotic cycles 12/13).

(Pae et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

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