FlyBase Allele Report: Dmel\Su(var)3-3[HMS00638]

General Information

Symbol

Dmel\Su(var)3-3^HMS00638

Species

D. melanogaster

Name

FlyBase ID

FBal0257322

Feature type

allele

Associated gene

Dmel\Su(var)3-3

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00638}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00638}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00638

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^{R521C.UAS.Tag:HA}

(Periz et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Su(var)3-3^HMS00638 under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} in female germlines does not result in defective karyosome morphology.

(Zhaunova et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Scer\GAL4^wor.PA, Su(var)3-3^HMS00638, Scer\GAL80^ase.PN is a non-enhancer of increased cell number | larval stage | dominant phenotype of ham²

(Rives-Quinto et al., 2020)

Su(var)3-3^HMS00638, Scer\GAL4^{VP16.nanos.UTR} is a non-enhancer of female sterile phenotype of Kdm5^GLV21071, Scer\GAL4^{VP16.nanos.UTR}

(Zhaunova et al., 2016)

NOT Suppressor of

Statement

Reference

Scer\GAL4^wor.PA, Su(var)3-3^HMS00638, Scer\GAL80^ase.PN is a non-suppressor of increased cell number | dominant | larval stage phenotype of ham²

(Rives-Quinto et al., 2020)

Su(var)3-3^HMS00638, Scer\GAL4^{VP16.nanos.UTR} is a non-suppressor of female sterile phenotype of Kdm5^GLV21071, Scer\GAL4^{VP16.nanos.UTR}

(Zhaunova et al., 2016)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Scer\GAL4^wor.PA, Su(var)3-3^HMS00638, Scer\GAL80^ase.PN is a non-enhancer of type II neuroblast | larval stage | increased number phenotype of ham²

(Rives-Quinto et al., 2020)

Scer\GAL4^wor.PA, Su(var)3-3^HMS00638, Scer\GAL80^ase.PN is a non-enhancer of larval brain | larval stage phenotype of ham²

(Rives-Quinto et al., 2020)

Su(var)3-3^HMS00638, Scer\GAL4^{VP16.nanos.UTR} is a non-enhancer of karyosome | adult stage phenotype of Kdm5^GLV21071, Scer\GAL4^{VP16.nanos.UTR}

(Zhaunova et al., 2016)

NOT Suppressor of

Statement

Reference

Scer\GAL4^wor.PA, Su(var)3-3^HMS00638, Scer\GAL80^ase.PN is a non-suppressor of type II neuroblast | increased number | larval stage phenotype of ham²

(Rives-Quinto et al., 2020)

Scer\GAL4^wor.PA, Su(var)3-3^HMS00638, Scer\GAL80^ase.PN is a non-suppressor of larval brain | larval stage phenotype of ham²

(Rives-Quinto et al., 2020)

Su(var)3-3^HMS00638, Scer\GAL4^{VP16.nanos.UTR} is a non-suppressor of karyosome | adult stage phenotype of Kdm5^GLV21071, Scer\GAL4^{VP16.nanos.UTR}

(Zhaunova et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Su(var)3-3^HMS00638 does not enhance or suppress the defective karyosome morphology seen in flies expressing lid^GLV21071 under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16}.

(Zhaunova et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

32853