FlyBase Allele Report: Dmel\Usp7[HMS01187]

General Information

Symbol

Dmel\Usp7^HMS01187

Species

D. melanogaster

Name

FlyBase ID

FBal0257845

Feature type

allele

Associated gene

Dmel\Usp7

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01187}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01187}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01187

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^{M337V.UAS.Tag:MYC}

(Zhang et al., 2020)

modeled by Hsap\SOD1^A4V.UAS

(Zhang et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

(Lake et al., 2024)

fertile, with Scer\GAL4^{VP16.nanos.UTR}

(Lake et al., 2024)

Phenotype Manifest In

synaptonemal complex | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

(Lake et al., 2024)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^{VP16.nanos.UTR}, Usp7^HMS01187 has abnormal meiotic cell cycle | oogenesis phenotype, non-enhanceable by vilya⁸²⁶/vilya⁸²⁶

(Lake et al., 2024)

NOT suppressed by

Statement

Reference

Scer\GAL4^{VP16.nanos.UTR}, Usp7^HMS01187 has abnormal meiotic cell cycle | oogenesis phenotype, non-suppressible by vilya⁸²⁶/vilya⁸²⁶

(Lake et al., 2024)

Suppressor of

Statement

Reference

Usp7^HMS01187, Scer\GAL4^Toll-6-D42 is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\SOD1^A4V.UAS, Scer\GAL4^Toll-6-D42

(Zhang et al., 2020)

Usp7^HMS01187, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Zhang et al., 2020)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^{VP16.nanos.UTR}, Usp7^HMS01187 has synaptonemal complex | oogenesis phenotype, non-enhanceable by vilya⁸²⁶/vilya⁸²⁶

(Lake et al., 2024)

NOT suppressed by

Statement

Reference

Scer\GAL4^{VP16.nanos.UTR}, Usp7^HMS01187 has synaptonemal complex | oogenesis phenotype, non-suppressible by vilya⁸²⁶/vilya⁸²⁶

(Lake et al., 2024)

Suppressor of

Statement

Reference

Usp7^HMS01187, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Zhang et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

34708

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01187}attP2

NIG-Fly

HMS01187

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01187}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Usp7^HMS01187

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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