FlyBase Allele Report: Dmel\Atg2[HMS01198]

General Information

Symbol

Dmel\Atg2^HMS01198

Species

D. melanogaster

Name

FlyBase ID

FBal0257856

Feature type

allele

Associated gene

Dmel\Atg2

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01198}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01198}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01198

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Cunningham et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

autophagosome | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Kuhn et al., 2015)

embryo | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Kuhn et al., 2015)

Detailed Description

Statement

Reference

Adult females expressing Atg2^HMS01198 under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} produce embryos that show a drastic decrease in the autophagosome formation at cellularization and show signs of organelle disorganization (the cellularization process itself appears to be unaffected). However, the embryo hatching rate is normal.

(Kuhn et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Atg2^HMS01198, Scer\GAL4^{VP16.mat.αTub67C} is a non-suppressor | maternal effect of majority die during embryonic stage | maternal effect phenotype of Scer\GAL4^{VP16.mat.αTub67C}, mTor^TRiP.cUa

(Kuhn et al., 2015)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The low hatching rate of embryos from mothers expressing either Tor^TRiP.cUa or Atg1^TRiP.cUa under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} cannot be rescued by co-expression of Atg2^HMS01198 (which on its own does not cause any significant hatching rate defects).

(Kuhn et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

34719