FlyBase Allele Report: Dmel\Xrp1[HMS00053]

General Information

Symbol

Dmel\Xrp1^HMS00053

Species

D. melanogaster

Name

FlyBase ID

FBal0263081

Feature type

allele

Associated gene

Dmel\Xrp1

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00053}

Also Known As

UAS-Xrp1^RNAi, UAS-Xrp1RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS00053}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00053

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 6

modeled by caz²

(Mallik et al., 2018)

modeled by Hsap\FUS^{R518K.UAS.Tag:HA}

(Mallik et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav-C155

(Mallik et al., 2018)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^Toll-6-D42

(Mallik et al., 2018)

long lived | male limited, with Scer\GAL4^Toll-6-D42

(Mallik et al., 2018)

short lived | female limited, with Scer\GAL4^Toll-6-D42

(Mallik et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing Xrp1^HMS00053 under the control of Scer\GAL4^elav-C155 present a significant decrease in climbing ability (i.e. speed) but do not show any obvious change in lifespan, as compared to controls.

Adults expressing Xrp1^HMS00053 under the control of Scer\GAL4^Toll-6-D42 show a progressive decrease in locomotor ability (i.e. a significant decrease in speed in 16 days old adults, but not in 10 days old adults), as compared to controls; larvae do not show significant crawling ability defects compared to controls.

(Mallik et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^elav-C155, Xrp1^HMS00053 has abnormal locomotor behavior | adult stage phenotype, enhanceable by caz²/caz²

(Mallik et al., 2018)

Scer\GAL4^elav-C155, Xrp1^HMS00053 has abnormal locomotor behavior | adult stage phenotype, enhanceable by caz^KO/caz^KO

(Mallik et al., 2018)

Suppressed by

Statement

Reference

Scer\GAL4^Toll-6-D42, Xrp1^HMS00053 has long lived | male limited phenotype, suppressible by Hsap\FUS^{R518K.UAS.Tag:HA}, Scer\GAL4^Toll-6-D42

(Mallik et al., 2018)

NOT suppressed by

Statement

Reference

Scer\GAL4^Toll-6-D42, Xrp1^HMS00053 has short lived | female limited phenotype, non-suppressible by Hsap\FUS^{R518K.UAS.Tag:HA}, Scer\GAL4^Toll-6-D42

(Mallik et al., 2018)

Scer\GAL4^Toll-6-D42, Xrp1^HMS00053 has abnormal locomotor behavior | adult stage | progressive phenotype, non-suppressible by Hsap\FUS^{R518K.UAS.Tag:HA}, Scer\GAL4^Toll-6-D42

(Mallik et al., 2018)

Suppressor of

Statement

Reference

Xrp1^HMS00053, Scer\GAL4^hh.PU is a suppressor of increased cell death | larval stage phenotype of Paip1^GD13792, Scer\GAL4^hh.PU

(Xue et al., 2023)

Scer\GAL4^ci.PC/Xrp1^HMS00053 is a suppressor | partially of increased cell death | somatic clone | larval stage phenotype of RpS23^R67K

(Recasens-Alvarez et al., 2021)

Scer\GAL4^elav-C155/Xrp1^HMS00053 is a suppressor of lethal - all die during pupal stage phenotype of caz²

(Mallik et al., 2018)

Xrp1^HMS00053/Scer\GAL4^Toll-6-D42 is a suppressor of abnormal locomotor behavior | larval stage phenotype of caz^KO

(Mallik et al., 2018)

Xrp1^HMS00053, Scer\GAL4^Toll-6-D42 is a suppressor | male | female | partially of short lived phenotype of Hsap\FUS^{R518K.UAS.Tag:HA}, Scer\GAL4^Toll-6-D42

(Mallik et al., 2018)

Xrp1^HMS00053, Scer\GAL4^Toll-6-D42 is a suppressor | partially of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\FUS^{R518K.UAS.Tag:HA}, Scer\GAL4^Toll-6-D42

(Mallik et al., 2018)

NOT Suppressor of

Statement

Reference

Scer\GAL4^repo.PU/Xrp1^HMS00053 is a non-suppressor of lethal - all die during pupal stage phenotype of caz²

(Mallik et al., 2018)

Other

Statement

Reference

Scer\GAL4^elav-C155, Xrp1^HMS00053, caz² has short lived phenotype

(Mallik et al., 2018)

Scer\GAL4^elav-C155, Xrp1^HMS00053, caz^KO has short lived phenotype

(Mallik et al., 2018)

Phenotype Manifest In

Suppressor of

Statement

Reference

Xrp1^HMS00053, Scer\GAL4^hh.PU is a suppressor of wing disc posterior compartment | larval stage phenotype of Paip1^GD13792, Scer\GAL4^hh.PU

(Xue et al., 2023)

Scer\GAL4^ci.PC/Xrp1^HMS00053 is a suppressor | partially of imaginal disc phenotype of RpS23^R67K

(Recasens-Alvarez et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

caz² males rescued to adulthood by the expression of Xrp1^HMS00053 under the control of Scer\GAL4^elav-C155 are short lived and show significant decreases in adult climbing ability (i.e. speed), as compared to controls.

(Mallik et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

34521

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00053}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Xrp1^HMS00053

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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