FB2025_01 , released February 20, 2025
Allele: Dmel\iPLA2-VIAHMS01544
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General Information
Symbol
Dmel\iPLA2-VIAHMS01544
Species
D. melanogaster
Name
FlyBase ID
FBal0263447
Feature type
allele
Associated gene
Dmel\iPLA2-VIA
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS01544}
Also Known As
HMS01544
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
in vitro construct
(Ni et al., 2011.7.19)
Progenitor genotype
Carried in construct
P{TRiP.HMS01544}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS01544
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing iPLA2-VIAHMS01544 under the control of Scer\GAL4Tub.PU or Scer\GAL4DJ667 show a progressive decrease in climbing activity in both males and females. Adults expressing iPLA2-VIAHMS01544 under the control of Scer\GAL4elav.PU show a progressive decrease in climbing activity only in males.

      (Banerjee et al., 2021)

      The expression of iPLA2-VIAHMS01544 under the control of either Scer\GAL4elav-C155 or Scer\GAL4da.G32 leads to adults exhibiting impaired locomotor behavior, as shown by a progressive and significant decrease in climbing capacity, as compared to controls. These adults also show a progressive accumulation of apoptotic cells in the brain, as compared to controls.

      (Iliadi et al., 2018)

      Ubiquitous expression of iPLA2-VIAHMS01544 under the control of Scer\GAL4Act5C.PU is associated with an age-dependent decrease in climbing ability and shortened lifespan.

      Expression of iPLA2-VIAHMS01544 under the control of Scer\GAL4elav-C155 results in a significant reduction in lifespan in flies compared with wild-type.

      (Kinghorn et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      iPLA2-VIAHMS01544
      Name Synonyms
      Secondary FlyBase IDs
        References (8)