FlyBase Allele Report: Dmel\PGRP-LF[200]

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Allele: Dmel\PGRP-LF²⁰⁰

General Information

Symbol

Dmel\PGRP-LF²⁰⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0267523

Feature type

allele

Associated gene

Associated Insertion(s)

P{GawB.Δ200}PGRP-LF²⁰⁰

Carried in Construct

Key Links

Allele class

hypermorphic allele - molecular evidence

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypermorphic allele - molecular evidence

(Tavignot et al., 2017)

hypomorphic allele - genetic evidence

(Maillet et al., 2008)

Mutagen

P-element activity

(Maillet et al., 2008)

Progenitor genotype

(Maillet et al., 2008)

Associated Insertion(s)

P{GawB.Δ200}PGRP-LF²⁰⁰

Cytology

Description

Internal deletion within the P{GawB} element in the progenitor P{GawB}DJ646 insertion, removing part of the w^+mW.hs marker sequence.

(Tavignot et al., 2017)

Excision of the P{GawB} element in P{GawB}DJ646 has resulted in a deletion of around 1500 base pairs, 900 bases upstream of the PGRP-LF transcription start site.

(Maillet et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Arefin et al., 2014)

partially lethal - majority die

(Maillet et al., 2008)

visible | adult stage

(Maillet et al., 2008)

visible | adult stage (with Df(3L)AC1)

(Maillet et al., 2008)

Phenotype Manifest In

(Maillet et al., 2008)

wing (with Df(3L)AC1)

(Maillet et al., 2008)

Detailed Description

Statement

Reference

PGRP-LF²⁰⁰ mutants show increased sensitivity relative to wild-type towards nemato-bacterial infections.

(Arefin et al., 2014)

The few PGRP-LF²⁰⁰ escapers that are seen show wing notching all around the wing margin. This wing margin phenotype is slightly enhanced when in PGRP-LF²⁰⁰/Df(3L)AC1 flies.

(Maillet et al., 2008)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

PGRP-LF²⁰⁰ has partially lethal - majority die phenotype, suppressible by imd¹

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has visible | adult stage phenotype, suppressible by imd¹

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has partially lethal - majority die phenotype, suppressible by Tak1¹

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has visible | adult stage phenotype, suppressible by Tak1¹

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has partially lethal - majority die phenotype, suppressible by hep¹

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has visible | adult stage phenotype, suppressible by hep¹

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has partially lethal - majority die phenotype, suppressible by Dredd^B118

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has partially lethal - majority die phenotype, suppressible by key¹

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has partially lethal - majority die phenotype, suppressible by Rel^E20

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has partially lethal - majority die phenotype, suppressible by PGRP-LE¹¹²

(Maillet et al., 2008)

NOT suppressed by

Statement

Reference

PGRP-LF²⁰⁰ has visible | adult stage phenotype, non-suppressible by Dredd^B118

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has visible | adult stage phenotype, non-suppressible by key¹

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has visible | adult stage phenotype, non-suppressible by Rel^E20

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has visible | adult stage phenotype, non-suppressible by PGRP-LE¹¹²

(Maillet et al., 2008)

Other

Statement

Reference

PGRP-LF²⁰⁰, Tep2^d11521 has abnormal immune response phenotype

(Arefin et al., 2014)

Phenotype Manifest In

Suppressed by

Statement

Reference

PGRP-LF²⁰⁰ has wing phenotype, suppressible by hep¹

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has wing phenotype, suppressible by imd¹

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has wing phenotype, suppressible by Tak1¹

(Maillet et al., 2008)

NOT suppressed by

Statement

Reference

PGRP-LF²⁰⁰ has wing phenotype, non-suppressible by Dredd^B118

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has wing phenotype, non-suppressible by key¹

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has wing phenotype, non-suppressible by Rel^E20

(Maillet et al., 2008)

PGRP-LF²⁰⁰ has wing phenotype, non-suppressible by PGRP-LE¹¹²

(Maillet et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

imd¹ suppresses the notching phenotypes and low adult viability seen in homozygous PGRP-LF²⁰⁰ mutants.

Tak1¹ suppresses the notching phenotypes and low adult viability seen in homozygous PGRP-LF²⁰⁰ mutants.

hep¹ suppresses the notching phenotypes and low adult viability seen in homozygous PGRP-LF²⁰⁰ mutants.

Dredd^B118 does not suppress the notching phenotypes and low adult viability seen in homozygous PGRP-LF²⁰⁰ mutants.

key¹ does not suppress the notching phenotypes and low adult viability seen in homozygous PGRP-LF²⁰⁰ mutants.

Rel^E20 does not suppress the notching phenotypes and low adult viability seen in homozygous PGRP-LF²⁰⁰ mutants.

PGRP-LE¹¹² does not suppress the notching phenotypes and low adult viability seen in homozygous PGRP-LF²⁰⁰ mutants.

(Maillet et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

PGRP-LF²⁰⁰ is rescued by Scer\GAL4^ap-md544/PGRP-LF^UAS.GFP

(Maillet et al., 2008)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

PGRP-LF²⁰⁰

(Tavignot et al., 2017, Arefin et al., 2014, Maillet et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections