FB2025_01 , released February 20, 2025
Allele: Dmel\sqaT279A.UAS
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General Information
Symbol
Dmel\sqaT279A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0267528
Feature type
allele
Associated gene
Dmel\sqa
Associated Insertion(s)
Carried in Construct
P{UAS-sqa.T279A}
Key Links
Transgenic product class
missense_variant
(Tang et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Tang et al., 2011)
Mutagen
in vitro construct
(Tang et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-sqa.T279A}
Cytology
Description

UAS regulatory sequences drive expression of sqa carrying a Thr-279-Ala amino acid substitution.

(Tang et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
sqa
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Clonal expression of sqaT279A.Scer\UAS under the control of Scer\GAL4Act5C.PP appears to block the formation of autophagy-related vesicles in larval fat bodies under starvation conditions compared with wild-type.

      Compared with wild-type flies, those expressing sqaT279A.Scer\UAS under the control of Scer\GAL4Cg.PA show a significantly shortened lifespan under starvation conditions.

      (Tang et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Scer\GAL4Act5C.PP, sqaT279A.UAS has fat body | somatic clone | calorie restriction conditional phenotype, suppressible | partially by sqhT20E.S21E.UAS/Scer\GAL4Act5C.PP

      (Tang et al., 2011)

      Scer\GAL4Act5C.PP, sqaT279A.UAS has autophagosome | somatic clone | calorie restriction conditional phenotype, suppressible | partially by sqhT20E.S21E.UAS/Scer\GAL4Act5C.PP

      (Tang et al., 2011)
      Suppressor of
      Statement
      Reference

      sqaT279A.UAS, Scer\GAL4Act5C.PP is a suppressor of fat body | somatic clone | calorie restriction conditional phenotype of Atg12RNAi.UAS, Scer\GAL4Act5C.PP

      (Tang et al., 2011)

      sqaT279A.UAS, Scer\GAL4Act5C.PP is a suppressor of autophagosome | somatic clone | calorie restriction conditional phenotype of Atg12RNAi.UAS, Scer\GAL4Act5C.PP

      (Tang et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of sqaT279A.Scer\UAS with Atg12dsRNA.Scer\UAS under the control of Scer\GAL4Act5C.PP significantly suppresses the Atg12dsRNA.Scer\UAS-induced fat body phenotype.

      Co-expression of sqhT20E.S21E.Scer\UAS with sqaT279A.Scer\UAS under the control of Scer\GAL4Act5C.PP partially suppresses the sqaT279A.Scer\UAS-induced autophagic defects in larval fat body cells.

      (Tang et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sqaT279A.Scer\UAS
      sqaT279A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)