FlyBase Allele Report: Dmel\Fatp1[HMC03111]

General Information

Symbol

Dmel\Fatp1^HMC03111

Species

D. melanogaster

Name

FlyBase ID

FBal0292323

Feature type

allele

Associated gene

Dmel\Fatp1

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC03111}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMC03111}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC03111

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Fatp1^HMC03111 under the control of Scer\GAL4^GMR.long does not induce any obvious eye phenotype, as compared to controls.

(Yan et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Fatp1^HMC03111/Scer\GAL4^ey.PU is a suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of sicily^E

(Liu et al., 2017)

Fatp1^HMC03111/Scer\GAL4^ey.PU is a suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of Marf^B

(Liu et al., 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^54C/Fatp1^HMC03111 is a suppressor of adult optic lobe glial cell | cell non-autonomous phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Scer\GAL4^54C/Fatp1^HMC03111 is a suppressor of lipid droplet | cell non-autonomous | adult stage phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Fatp1^HMC03111/Scer\GAL4^ey.PU is a suppressor of lipid droplet | somatic clone | adult stage phenotype of Marf^B

(Liu et al., 2017)

Fatp1^HMC03111/Scer\GAL4^ey.PU is a suppressor of photoreceptor | somatic clone | adult stage | progressive phenotype of Marf^B

(Liu et al., 2017)

Scer\GAL4^elav.PLu/Fatp1^HMC03111 is a suppressor of adult optic lobe glial cell | cell non-autonomous phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Scer\GAL4^elav.PLu/Fatp1^HMC03111 is a suppressor of lipid droplet | cell non-autonomous | adult stage phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Fatp1^HMC03111/Scer\GAL4^ey.PU is a suppressor of adult optic lobe glial cell | somatic clone phenotype of sicily^E

(Liu et al., 2017)

Fatp1^HMC03111/Scer\GAL4^ey.PU is a suppressor of lipid droplet | somatic clone | adult stage phenotype of sicily^E

(Liu et al., 2017)

Fatp1^HMC03111/Scer\GAL4^ey.PU is a suppressor of photoreceptor | somatic clone | adult stage | progressive phenotype of sicily^E

(Liu et al., 2017)

Fatp1^HMC03111/Scer\GAL4^ey.PU is a suppressor of adult optic lobe glial cell | somatic clone phenotype of Marf^B

(Liu et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The accumulation of lipid droplets in glial cells in the vicinity of adult photoreceptor neurons expressing ND-42^ninaE.GD6220 is ameliorated by the expression of Fatp^HMC03111 when driven by either Scer\GAL4^54C or Scer\GAL4^elav.PLu.

Expression of Fatp^HMC03111 in the ey>flip whole-eye clones mutant for either sicily^E or Marf^B ameliorates the lipid droplet accumulation in retinal glial cells in adult flies and also improves the photoreceptor degeneration phenotype.

(Liu et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

50709