FB2025_01 , released February 20, 2025
Allele: Dmel\PlexBUAS.cUa
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General Information
Symbol
Dmel\PlexBUAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0303929
Feature type
allele
Associated gene
Dmel\PlexB
Associated Insertion(s)
Carried in Construct
P{UAS-plexB.U}
Key Links
Transgenic product class
wild_type
(Bates and Whitington, 2007)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Bates and Whitington, 2007)
Mutagen
in vitro construct
(Bates and Whitington, 2007)
Progenitor genotype
Carried in construct
P{UAS-plexB.U}
Cytology
Description

UAS regulatory sequences drive expression of PlexB coding sequences.

(Bates and Whitington, 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
PlexB
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of PlexBScer\UAS.cUa in all neurons (under the control of Scer\GAL4elav.PLu) or in sensory neurons specifically (under the control of Scer\GAL412.1) does not result in a significant number of sensory axon mis-projections or stalls.

      Expression of two copies of PlexBScer\UAS.cUa under the control of two copies of Scer\GAL4elav.PLu results in both lateral (5.7%) and dorsal sensory axon mis-projections and/or stalls (2.9%). The frequency of lateral defects in these embryos is significantly higher than in control embryos.

      (Bates and Whitington, 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      PlexBUAS.cUa/Scer\GAL412.1 rescues PlexBKG00878

      (Bates and Whitington, 2007)
      Comments

      Expression of PlexBScer\UAS.cUa in sensory neurons (under the control of Scer\GAL412.1) results in the frequency of the v'ch1 mis-projection phenotype decreasing from 14/7% to 4.8% in a PlexBKG00878 background.

      (Bates and Whitington, 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PlexBScer\UAS.cUa
      PlexBUAS.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)