FlyBase Allele Report: Dmel\ap[EY03046]

General Information

Symbol

Dmel\ap^EY03046

Species

D. melanogaster

Name

FlyBase ID

FBal0304931

Feature type

allele

Associated gene

Dmel\ap

Associated Insertion(s)

P{EPgy2}ap^EY03046

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Bieli et al., 2015)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}ap^EY03046

Cytology

Description

Inserted several hundred bp upstream of ap. The direction of the Scer\UAS-cassette is in the opposite orientation to the direction of transcription of ap.

(Bieli et al., 2015)

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:5,727,302..5,727,302 [+]

(Bieli et al., 2015)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^Act5C.PI

(Bieli et al., 2015)

visible, with Scer\GAL4^Dad.4

(Bieli et al., 2015)

visible, with Scer\GAL4^dpp.blk1

(Bieli et al., 2015)

visible, with Scer\GAL4^ptc-559.1

(Bieli et al., 2015)

visible, with Scer\GAL4^salm.E

(Bieli et al., 2015)

Phenotype Manifest In

wing, with Scer\GAL4^Act5C.PI

(Bieli et al., 2015)

wing blade, with Scer\GAL4^Dad.4

(Bieli et al., 2015)

wing blade, with Scer\GAL4^salm.E

(Bieli et al., 2015)

wing margin, with Scer\GAL4^ptc-559.1

(Bieli et al., 2015)

wing margin bristle | increased number, with Scer\GAL4^dpp.blk1

(Bieli et al., 2015)

Detailed Description

Statement

Reference

Expression of Scer\GAL4^Act5C.PI>ap^EY03046 in the wing pouch abolishes wing margin formation in the tiny adult wings.

Expression of Scer\GAL4^Dad.4>ap^EY03046 results in mitten-shaped wing.

Expression of Scer\GAL4^salm.E>ap^EY03046 results in the loss of distal wing tissue.

A tuft of ectopic bristles is observed on the ventral side of the intersection of the anterior-posterior (A-P) boundary and the wing margin in less than 10% of adult wings expressing Scer\GAL4^dpp.blk1>ap^EY03046.

Wings of flies expressing Scer\GAL4^ptc-559.1>ap^EY03046 often form three-dimensional, balloon-like structures with an oval-shaped posterior margin extending from the proximal edge of the wing appendage to its distal end and back to proximal. In addition, anterior and posterior margins are not continuous at the tip of the wing.

(Bieli et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

15619

y¹ w^67c23; P{EPgy2}ap^EY03046

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ap^EY03046

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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