FlyBase Allele Report: Dmel\Tace[1]

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Allele: Dmel\Tace¹

General Information

Symbol

Dmel\Tace¹

Species

D. melanogaster

Name

FlyBase ID

FBal0362677

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

(Muliyil et al., 2020)

Progenitor genotype

Cytology

Description

5bp deletion within Tace; results in a premature stop codon.

(Muliyil et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye photoreceptor cell | decreased number

(Muliyil et al., 2020)

eye photoreceptor cell | decreased number (with Df(3R)BSC794)

(Muliyil et al., 2020)

lipid droplet | adult stage | increased number

(Muliyil et al., 2020)

lipid droplet | adult stage | increased number (with Df(3R)BSC794)

(Muliyil et al., 2020)

pigment cell | decreased number

(Muliyil et al., 2020)

pigment cell | decreased number (with Df(3R)BSC794)

(Muliyil et al., 2020)

(Muliyil et al., 2020)

retina (with Df(3R)BSC794)

(Muliyil et al., 2020)

Detailed Description

Statement

Reference

Tace¹ homozygous and Tace¹/Df(3R)BSC794 retinas exhibit degeneration of both photoreceptor cells and the surrounding pigmented glial cells (pigment cells) in 5-week-old flies while they exhibit enlarged pigment cells with accumulated lipid droplets in 1-day-old flies when compared to controls.

Tace¹ homozygotes raised in dark exhibit almost complete rescue of degeneration and a partial rescue of lipid droplet accumulation in retina.

(Muliyil et al., 2020)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Tace¹ has abnormal neuroanatomy | adult stage | progressive phenotype, suppressible by Scer\GAL4^sv.PJ/bmm^UAS.cGa

(Muliyil et al., 2020)

Tace¹ has decreased cell number | adult stage | progressive phenotype, suppressible by Scer\GAL4^sv.PJ/bmm^UAS.cGa

(Muliyil et al., 2020)

Tace¹ has abnormal neuroanatomy | adult stage | progressive phenotype, suppressible | partially by bmm^UAS.cGa/Scer\GAL4^elav.PLu

(Muliyil et al., 2020)

Tace¹ has decreased cell number | adult stage | progressive phenotype, suppressible | partially by bmm^UAS.cGa/Scer\GAL4^elav.PLu

(Muliyil et al., 2020)

Tace¹ has abnormal neuroanatomy | adult stage | progressive phenotype, suppressible by Scer\GAL4^sv.PJ/Sod2^UAS.cMa

(Muliyil et al., 2020)

Tace¹ has decreased cell number | adult stage | progressive phenotype, suppressible by Scer\GAL4^sv.PJ/Sod2^UAS.cMa

(Muliyil et al., 2020)

Tace¹ has abnormal neuroanatomy | adult stage | progressive phenotype, suppressible by bsk¹

(Muliyil et al., 2020)

Tace¹ has decreased cell number | adult stage | progressive phenotype, suppressible by bsk¹

(Muliyil et al., 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

Tace¹ has lipid droplet | increased number | adult stage phenotype, suppressible by Scer\GAL4^sv.PJ/bmm^UAS.cGa

(Muliyil et al., 2020)

Tace¹ has lipid droplet | increased number | adult stage phenotype, suppressible | partially by Sod2^UAS.cMa/Scer\GAL4^elav.PLu

(Muliyil et al., 2020)

Tace¹ has lipid droplet | increased number | adult stage phenotype, suppressible by Scer\GAL4^sv.PJ/Sod2^UAS.cMa

(Muliyil et al., 2020)

Tace¹ has lipid droplet | increased number | adult stage phenotype, suppressible | partially by Scer\GAL4^sv.PJ/Sod1^UAS.cUa

(Muliyil et al., 2020)

Tace¹ has eye photoreceptor cell | decreased number phenotype, suppressible by Scer\GAL4^sv.PJ/Sod2^UAS.cMa

(Muliyil et al., 2020)

Tace¹ has retina phenotype, suppressible | partially by Scer\GAL4^sv.PJ/Cat^UAS.cAa

(Muliyil et al., 2020)

Tace¹ has lipid droplet | increased number | adult stage phenotype, suppressible | partially by Scer\GAL4^sv.PJ/Cat^UAS.cAa

(Muliyil et al., 2020)

Tace¹ has retina phenotype, suppressible by bsk¹

(Muliyil et al., 2020)

Tace¹ has eye photoreceptor cell | decreased number phenotype, suppressible by bsk¹

(Muliyil et al., 2020)

Tace¹ has lipid droplet | increased number | adult stage phenotype, suppressible by bsk¹

(Muliyil et al., 2020)

Tace¹ has pigment cell | decreased number phenotype, suppressible by Scer\GAL4^sv.PJ/bmm^UAS.cGa

(Muliyil et al., 2020)

Tace¹ has eye photoreceptor cell | decreased number phenotype, suppressible by Scer\GAL4^sv.PJ/bmm^UAS.cGa

(Muliyil et al., 2020)

Tace¹ has retina phenotype, suppressible by Scer\GAL4^sv.PJ/bmm^UAS.cGa

(Muliyil et al., 2020)

Tace¹ has eye photoreceptor cell | decreased number phenotype, suppressible | partially by bmm^UAS.cGa/Scer\GAL4^elav.PLu

(Muliyil et al., 2020)

Tace¹ has retina phenotype, suppressible | partially by bmm^UAS.cGa/Scer\GAL4^elav.PLu

(Muliyil et al., 2020)

Tace¹ has retina phenotype, suppressible | partially by Sod2^UAS.cMa/Scer\GAL4^elav.PLu

(Muliyil et al., 2020)

Tace¹ has retina phenotype, suppressible by Scer\GAL4^sv.PJ/Sod2^UAS.cMa

(Muliyil et al., 2020)

Tace¹ has retina phenotype, suppressible | partially by Scer\GAL4^sv.PJ/Sod1^UAS.cUa

(Muliyil et al., 2020)

NOT suppressed by

Statement

Reference

Tace¹ has lipid droplet | increased number | adult stage phenotype, non-suppressible by bmm^UAS.cGa/Scer\GAL4^elav.PLu

(Muliyil et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Tace¹ is rescued by Scer\GAL4^sv.PJ/Tace^UAS.cMa

(Muliyil et al., 2020)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ADAM17¹

(Muliyil et al., 2020)

Tace¹

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections