FlyBase Allele Report: Dmel\Otud6[C183A]

General Information

Symbol

Dmel\Otud6^C183A

Species

D. melanogaster

Name

FlyBase ID

FBal0405271

Feature type

allele

Associated gene

Dmel\Otud6

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Villa et al., 2024)

gene targeting by homologous recombination

(Villa et al., 2024)

Progenitor genotype

Cytology

Description

Amino acid replacement: C183A.

(Villa et al., 2024)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

MNV

3L:15,504,266..15,504,267 [-]

Nucleotide change:

TG15504267GC

Reported nucleotide change:

TG?GC

Amino acid change:

C183A | Otud6-PA

Reported amino acid change:

C183A

Comment:

Cys183 is replaced with Ala in Otud6. A silent substitution (C to T) at codon H190 was also introduced.

(Villa et al., 2024)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Otud6^C183A has chemical sensitive | adult stage phenotype, enhanceable by Bre1[+]/Bre1⁰¹⁶⁴⁰

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, enhanceable by Bre1[+]/Bre1⁰¹⁶⁴⁰

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, enhanceable by Su(dx)[+]/Su(dx)³²

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, enhanceable by Su(dx)[+]/Su(dx)³²

(Villa et al., 2024)

NOT Enhanced by

Statement

Reference

Otud6^C183A has chemical sensitive | adult stage phenotype, non-enhanceable by Su(dx)[+]/Su(dx)²

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, non-enhanceable by Su(dx)[+]/Su(dx)²

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, non-enhanceable by Ubc6^MI02360/Ubc6[+]

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, non-enhanceable by Ubc6^MI02360/Ubc6[+]

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, non-enhanceable by RpS7^K2R/RpS7^K2R

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, non-enhanceable by RpS7^K2R/RpS7^K2R

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, non-enhanceable by CG11414^EY11021/CG11414^EY11021

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, non-enhanceable by CG11414^EY11021/CG11414^EY11021

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, non-enhanceable by CG11414^HP25186/CG11414^HP25186

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, non-enhanceable by CG11414^HP25186/CG11414^HP25186

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, non-enhanceable by eff[+]/eff^mer4

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, non-enhanceable by eff[+]/eff^mer4

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, non-enhanceable by Nedd4[+]/Nedd4^EY00500

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, non-enhanceable by Nedd4[+]/Nedd4^EY00500

(Villa et al., 2024)

Suppressed by

Statement

Reference

Otud6^C183A has chemical sensitive | adult stage phenotype, suppressible by Df(2L)RACK1-mts/+

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, suppressible by Df(2L)RACK1-mts/+

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, suppressible by Rack1[+]/Rack1^EY00128

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, suppressible by Rack1[+]/Rack1^EY00128

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, suppressible by Cnot4[+]/Cnot4^cr

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, suppressible by CG12099[+]/CG12099^e00982

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, suppressible by Kpc1[+]/Kpc1^c06604

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, suppressible by CG12099[+]/CG12099^EY23523

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, suppressible by CG12099[+]/CG12099^e00982

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, suppressible by Cnot4[+]/Cnot4^cr

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, suppressible by CG12099[+]/CG12099^EY23523

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, suppressible by Kpc1[+]/Kpc1^c06604

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, suppressible by ago[+]/ago^EP1135

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, suppressible by ago[+]/ago^EY01092

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, suppressible by ago[+]/ago^EP1135

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, suppressible by ago[+]/ago^EY01092

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, suppressible | partially by Ubc6^EY04634/Ubc6[+]

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, suppressible | partially by Ubc6^EY04634/Ubc6[+]

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, suppressible by Dis3¹/Dis3[+]

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, suppressible by Dis3¹/Dis3[+]

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, suppressible by Dis3[+]/Dis3^G5039

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, suppressible by Dis3[+]/Dis3^G5039

(Villa et al., 2024)

NOT suppressed by

Statement

Reference

Otud6^C183A has chemical sensitive | adult stage phenotype, non-suppressible by CG11414^EY11021/CG11414^EY11021

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, non-suppressible by CG11414^EY11021/CG11414^EY11021

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, non-suppressible by Ubc6^MI02360/Ubc6[+]

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, non-suppressible by Ubc6^MI02360/Ubc6[+]

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, non-suppressible by RpS7^K2R/RpS7^K2R

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, non-suppressible by RpS7^K2R/RpS7^K2R

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, non-suppressible by CG11414^HP25186/CG11414^HP25186

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, non-suppressible by CG11414^HP25186/CG11414^HP25186

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, non-suppressible by eff[+]/eff^mer4

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, non-suppressible by eff[+]/eff^mer4

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, non-suppressible by Nedd4[+]/Nedd4^EY00500

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, non-suppressible by Nedd4[+]/Nedd4^EY00500

(Villa et al., 2024)

Otud6^C183A has chemical sensitive | adult stage phenotype, non-suppressible by Su(dx)[+]/Su(dx)²

(Villa et al., 2024)

Otud6^C183A has increased mortality | adult stage phenotype, non-suppressible by Su(dx)[+]/Su(dx)²

(Villa et al., 2024)

Enhancer of

Statement

Reference

Otud6^C183A is an enhancer of chemical sensitive | adult stage phenotype of RpS7^K2R

(Villa et al., 2024)

Otud6^C183A is an enhancer of increased mortality | adult stage phenotype of RpS7^K2R

(Villa et al., 2024)

Otud6^C183A/Otud6[+] is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PY, Zzzz\poly-GR^PO-36.UAS

(Villa et al., 2024)

Phenotype Manifest In

Enhancer of

Statement

Reference

Otud6^C183A/Otud6[+] is an enhancer of eye phenotype of Scer\GAL4^GMR.PY, Zzzz\poly-GR^PO-36.UAS

(Villa et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

605653

w^*; Otud6^C183A

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

OTUD6^C183A

(Villa et al., 2024)

Otud6^C183A

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections