FB2025_01 , released February 20, 2025
Pathway: UDP-N-ACETYLGLUCOSAMINE BIOSYNTHESIS
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General Information
Name
UDP-N-ACETYLGLUCOSAMINE BIOSYNTHESIS
Species
D. melanogaster
Symbol
UDPGLAB
FlyBase ID
FBgg0002050
Date last reviewed
2024-11-20
Number of members
9
Description
Description
The synthesis of the nucleotide-sugar UDP-N-acetylglucosamine (UDP-GlcNAc) can occur via de novo or salvage pathways in the cytosol. In the de novo pathway, which is the main one, D-glucose, L-glutamine, acetyl-CoA and UTP are used to produce UDP-GlcNAc. In the salvage pathway glucosamine and N-acetylglucosamine acquired from environmental sources or from the degradation of glycoconjugates can be used to produce UDP-GlcNAc. UDP-GlcNAc is a precursor for protein glycosylation and the biosynthesis of chitin, peptidoglycans and GPI-anchors. (Adapted from PMID:37107691.)
Notes

Hex-t1 and Hex-t2 are paralogs of Hex-A and Hex-C and are specifically expressed in testis. It is not clear if Hex-t1 is enzymatically active as the catalytic residue is not conserved. As there is no functional information, Hex-t1 and Hex-t2 are not included in the gene list.

Source Material
The UDP-N-ACETYLGLUCOSAMINE BIOSYNTHESIS Gene Group has been compiled using the following publication(s): Chen et al., 2020 and Mariappa et al., 2011 .
Key Gene Ontology (GO) terms
Biological Process
UDP-N-acetylglucosamine biosynthetic process
Cellular Component
cytosol
Related Gene Groups
GO Causal Activity Model (GO-CAM)
Members (9)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gfat1
Glutamine:fructose-6-phosphate aminotransferase 1
gfat, zep, zeppelin
(Chen et al., 2020)
Gfat2
Glutamine:fructose-6-phosphate aminotransferase 2
(Chen et al., 2020)
Gnpnat
Glucosamine-phosphate N-acetyltransferase
(FlyBase, 2024-)
Hex-A
Hexokinase A
HexA, HEX, hexokinase, HK, HK-A
(FlyBase, 2024-)
Hex-C
Hexokinase C
HEX, HexC, hexokinase, HK, HK-C
(FlyBase, 2024-)
mmy
mummy
cyst, cystic, cabrio, BcDNA:LD24639, cao
(Mariappa et al., 2011)
Nagk
N-acetylglucosamine kinase
(FlyBase, 2024-)
nst
nesthocker
(Mariappa et al., 2011)
Pgi
Phosphoglucose isomerase
Gpi, glucose phosphate isomerase
(FlyBase, 2024-)
External Data
Other resource(s)
Note: The Drosophila pathways shown at these resources are computed using different methods. They may therefore differ from the manually curated and verified pathway shown above.

[FlyCyc: UDP-N-acetyl-D-glucosamine biosynthesis II](https://biocyc.org/pathway?orgid=FLY&id=UDPNACETYLGALSYN-PWY)

[Reactome: Synthesis of UDP-N-acetyl-glucosamine](https://reactome.org/PathwayBrowser/#/R-DME-446210)

[KEGG: UDP-N-acetyl-D-glucosamine biosynthesis, eukaryotes](https://www.genome.jp/pathway/dme00520+M00892)

Synonyms and Secondary IDs
Synonym(s)
UDPGLAB
hexosamine biosynthesis pathway
UDP-N-ACETYLGLUCOSAMINE BIOSYNTHESIS
Secondary FlyBase ID(s)
References (4)