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Gene Dmel\rs

General Information
Symbol	Dmel\rs	Species	D. melanogaster
Name	rose	Annotation symbol
Feature type	gene	FlyBase ID	FBgn0003281
Gene Model Status	Unannotated	Stock availability	9 publicly available
Genomic Location
Chromosome (arm)		Recombination map	3-35.0
Cytogenetic map	68A2-68A2	Sequence location
Summary Information
Automatically generated summary See sections below for more information	The gene rose is referred to in FlyBase by the symbol Dmel\rs (FBgn0003281). It is a gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 3 alleles are reported. The phenotypes of these alleles are annotated with: Malpighian tubule; ocellus pigment granule; pigment cell. It has no annotated transcripts. Gene has not been localized to the genome sequence.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	*rs: rose Eye color translucent purplish pink and ocelli colorless immediately after hatching; darken with age becoming sepia like, at least in the case of rs66j. Further, rs66j displays markedly decreased xanthopterin levels, reduced drosopterins, and higher than normal levels of sepiapterin and biopterin (Thorig and Scharloo, 1971, DIS 46: 40). rs very clear when combined with v (Akam), also interacts strongly with ltd (Silva and Mensua, 1985, DIS 51: 156). Larval Malpighian tubes pale yellow (Brehme and Demerec, 1942, Growth 6: 351-56).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 68A2-68A2   Left limit from inclusion within Df(3L)lxd2 (FBrf0044475) Right limit from non-inclusion within Df(3L)vin5 (FBrf0031168)
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-35.0
Left of (cM)
Right of (cM)	cur (Schott et al., 1986)
Notes
Gene Model & Products
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Mapped Features
Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable | good rs2 Sterility Allele fertile | good rs2 male sterile | recessive rs1 Other Phenotypes Allele eye color defective rs1 rs2 rs66j visible | recessive rs1 rs2 visible | recessive | heat sensitive rs66j Phenotype manifest in Allele Malpighian tubule rs1 ocellus pigment granule rs2 rs66j pigment cell rs1 rs2 rs66j
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of rs Class Mutagen Stocks Known lesion rs2 spontaneous 9 -- rs1 spontaneous 0 -- rs66j spontaneous 0 --
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of rs Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Disrupted in	Df(3L)lxd2 (Crosby and Meyerowitz, 1986) Df(3L)lxd6 (Schott et al., 1986, Crosby and Meyerowitz, 1986) Df(3L)lxd9 (Crosby and Meyerowitz, 1986) Df(3L)lxd15 (Schott et al., 1986) Df(3L)vin2 (Akam et al., 1978, Schott et al., 1986) Df(3L)vin5 (Crosby and Meyerowitz, 1986)
Not disrupted in	Df(3L)lxd2 (Schott et al., 1986) Df(3L)lxd8 (Schott et al., 1986, Crosby and Meyerowitz, 1986) Df(3L)lxd9 (Schott et al., 1986) Df(3L)vin3 (Crosby and Meyerowitz, 1986) Df(3L)vin4 (Schott et al., 1986, Crosby and Meyerowitz, 1986) Df(3L)vin5 (Akam et al., 1978, Schott et al., 1986) Df(3L)vin6 (Crosby and Meyerowitz, 1986) Df(3L)vin7 (Crosby and Meyerowitz, 1986) Df(3L)vin66 (Schott et al., 1986)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions rs allele Gene References unspecified ltd (Silva and Mensua, 1985)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0003281
Orthologs
OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	573 rs2 593 se1 h2 rs2 7451 rs2 Sodn64 pp/TM3, SodF Sb1 Ser1 1047 rs2 bulD Crn1 in1 kniri-1/TM3, Sb1 Ser1
Kyoto	105987 rs2 106177 emcD rhove-1 rs2 st1 bulD/TM1 101736 rs2 Sodn58 pp / TM3, Sb1 Ser1 SodF pp 106181 rs2 bulD Crn1 in1 kniri-1/TM3, Sb1 Ser1 101582 C(3L)RM-H1, se1 h2 rs2 / C(3R)RM-P5, Sbsbd-1 gl1 es
Genomic Clones ( 0 )
cDNA Clones ( 0 )
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45355
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Pteridines (neodrosopterin, drosopterin, isodrosopterin, aurodrosopterin, 6-acetyl-dihydrohomopterin, sepiapterin, dihydrobiopterin, biopterin, pterin and isoxanthopterin) have been quantified in single and double mutants. (Silva and Mensua, 1985) It is likely that this gene is required for the normal transport of eye-pigment precursors. (Silva and Mensua, 1985) Eye color translucent purplish pink and ocelli colorless immediately after hatching; darken with age becoming sepia like, at least in the case of rs66j.
External Crossreferences & Linkouts
Sequence Crossreferences
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0003281 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45355
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	rs (Anaka et al., 2008)
Name Synonym	rose (Muraro and Moffat, 2006, Anaka et al., 2008)
Secondary FlyBase IDs
References ( 17 )
Research paper	Anaka et al., 2008, J. Neurogenet. 22(4): 243--276 The white gene of Drosophila melanogaster encodes a protein with a role in courtship behavior. [FBrf0207087] Muraro and Moffat, 2006, J. Neurobiol. 66(12): 1338--1353 Down-regulation of torp4a, encoding the Drosophila homologue of torsinA, results in increased neuronal degeneration. [FBrf0195378] Lin et al., 1996, Development 122(4): 1331--1341 Coordinate developmental control of the meiotic cell cycle and spermatid differentiation in Drosophila males. [FBrf0087570] Silva et al., 1991, Mol. Gen. Genet. 230: 97--103 Genetic and biochemical characterization of little isoxanthopterin (lix), a gene controlling dihydropterin oxidase activity in Drosophila melanogaster. [FBrf0054724] Aparisi and Najera, 1990, Genome 33(2): 203--208 Genetic location and biochemical characterization of eye-colour mutants from natural populations of Drosophila melanogaster. [FBrf0052044] Hoogwerf et al., 1988, Genetics 118: 665--670 A genetic analysis of the rose-gespleten region (68C8-69B5) of Drosophila melanogaster. [FBrf0048238] Crosby and Meyerowitz, 1986, Genetics 112: 785--802 Lethal mutations flanking the 68C glue gene cluster on chromosome 3 of Drosophila melanogaster. [FBrf0044475] Fuller, 1986, Gall, 1986: 19--41 Genetic analysis of spermatogenesis in Drosophila: The role of the testis-specific -tubulin and interacting genes in cellular morphogenesis. [FBrf0066557] Schott et al., 1986, Biochem. Genet. 24: 509--527 Molybdenum hydroxylases in Drosophila. [FBrf0043787] Silva and Mensua, 1985, D. I. S. 61: 156 Synergistic effects between eye-color genes of Drosophila melanogaster. [FBrf0042242] Akam et al., 1978, Cell 13: 215--225 Drosophila: the genetics of two major larval proteins. [FBrf0031168] Thorig and Scharloo, 1971, D. I. S. 46: 40 [New mutants report.] [FBrf0065709] Brehme and Demerec, 1942, Growth 6: 351--355 A survey of Malpighian tube color in the eye color mutants of Drosophila melanogaster. [FBrf0005752]
Review	Dean et al., 2001, Genome Res. 11: 1156--1166 The human ATP-binding cassette (ABC) transporter superfamily. [FBrf0159553] Spencer, 1949, Jepsen, Mayr, Simpson, 1949: 23--44 Gene homologies and mutants in Drosophila hydei. [FBrf0007487]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905] Morgan et al., 1925, Biblphia Genet. 2: 262pp The genetics of Drosophila melanogaster. [FBrf0001379]