FlyBase Gene Report: Dmel\CG43675

General Information

Symbol

Dmel\CG43675

Species

D. melanogaster

Name

Annotation Symbol

CG43675

Feature Type

protein_coding_gene

FlyBase ID

FBgn0263750

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

85D11-85D11

Sequence location

3R:9,355,495..9,359,189 [+]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:9355495..9359189

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG43675 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8INP3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.43

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.53

Multiphase exon postulated: this gene shares a region of coding sequence with an overlapping gene, but different reading frames are utilized in the overlapping coding region.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG43675-RB

FBtr0310402

NM_001031989

1628

372

CG43675-RC

FBtr0344371

NM_001300319

1820

372

CG43675-RD

FBtr0344372

NM_001031988

2529

372

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG43675-PB

FBpp0302550

38.7

372

12.28

FBpp0310744

38.7

372

12.28

FBpp0310745

38.7

372

12.28

Q8INP3

NP_001027159

AAN13419

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

372 aa isoforms: CG43675-PB, CG43675-PC, CG43675-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q8INP3

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG43675 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG43675_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.72

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG43675 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG43675

View exonic expression by tissue for Dmel\CG43675

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

14462445/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263750

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263750

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG43675

Transgenic constructs containing regulatory region of CG43675

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG43675^GD8590

viable, with Scer\GAL4^Mef2.PR

CG43675^GD8590

viable, with Scer\GAL4^pnr-MD237

CG43675^GD8590

viable, with Scer\GAL4^tin.CΔ4

CG43675^GD8590

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\ZFAND5

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Zfand5

1 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Zfand5

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\sipa1l3

1 of 13

Yes

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\F22D6.2

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG43675. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

CG15368

1 of 13

drn

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_dicistronic_mRNA

(FlyBase Genome Annotators, 2013)

nuclear_gene

(FlyBase Genome Annotators, 2012)

protein_coding_gene

(FlyBase Genome Annotators, 2012)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

85D11-85D11

Sequence location

3R:9,355,495..9,359,189 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

85D11-85D11

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-46.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

82759

y¹ sc^* v¹ sev²¹; P{TOE.GS05191}attP40

57462

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04772}attP40

FlyORF

F000136

M{UAS-CG43675.ORF.3xHA.GW}ZH-86Fb

VDRC

v103508

P{KK112404}VIE-260B

v19069

w¹¹¹⁸; P{GD8590}v19069/TM3

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (64)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0263750

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG16750 anon-85Da

(Bayraktaroglu, 2000.11.2)

Source for merge of: CG33188 BcDNA:RE70963

(FlyBase, 1996-)

Additional comments

One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG45050 and CG43675.

(FlyBase Genome Annotators, 2013)

Annotation CG33936 split into CG43674 and CG43675 in release 5.43 of the genome annotation.

(FlyBase Genome Annotators, 2012)

FlyBase curator comment: Correspondence with author Maeda revealed that 'drn' = 'CG33936'.

(Maeda et al., 2008)

Gene order: Overall orientation not stated: Fps85D+ CG8129- CG18473- CG33936-

(Murray et al., 2006)

Annotation CG33187 split into CG33936 and CG33937 in release 4.2 of the genome annotation. In addition, release 4.2 annotation CG33936 contains sequences corresponding to release 4.1 annotation CG33188

(FlyBase Genome Annotators, 2005)

Annotation CG16751 split into CG33187 and CG33188 in release 3 of the genome annotation. In addition, release 3 annotation CG33188 contains sequences correponding to release 2 annotation CG16750.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG33188 BcDNA:RE70963 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

BcDNA:RE70963

(FlyBase, 1996-)

CG16750

(Bonin and Mann, 2004, Demakov et al., 2004, FlyBase Genome Annotators, 2002-2003, Bayraktaroglu, 2000.11.2)

CG16751

(Demakov et al., 2004, Brody et al., 2002, FlyBase Genome Annotators, 2002-2003)

CG33187

(FlyBase Genome Annotators, 2005, FlyBase Genome Annotators, 2002-2003)

CG33188

(Khokhar et al., 2008, Isogai et al., 2007, Liebl et al., 2006, FlyBase Genome Annotators, 2005, Huang et al., 2005, Bonin and Mann, 2004, Demakov et al., 2004, Giot et al., 2003, FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)

CG3393

(Demakov et al., 2004)

CG33936

(Vidal et al., 2010, Dorus, 2008.10.28, Maeda et al., 2008, Buszczak et al., 2007, Dietzl et al., 2007, Dorus et al., 2006, Murray et al., 2006, FlyBase Genome Annotators, 2005, Bonin and Mann, 2004)

CG33937

(FlyBase Genome Annotators, 2005)

CG43675

(Meltzer et al., 2019, Transgenic RNAi Project members, 2017-, Schertel et al., 2015, FlyBase Genome Annotators, 2013, Ni et al., 2010.12.1)

anon-85Da

(Bayraktaroglu, 2000.11.2)

drn

(Maeda et al., 2008)

Name Synonyms

Secondary FlyBase IDs

FBgn0053936
FBgn0037681
FBgn0053188

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 24 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

14462445

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8INP3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q8INP3

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q8INP3

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

14462445/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263750

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263750

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG43675

MARRVEL_MODEL - MARRVEL (model organism gene)

14462445

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0263750

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG43675_1

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0263750

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

References (36)

The following external sites may use different assemblies or annotations than FlyBase.

4.72

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