Reference Report

Reference
Citation	Selvaraj, A., Balamurugan, K., Yepiskoposyan, H., Zhou, H., Egli, D., Georgiev, O., Thiele, D.J., Schaffner, W. (2005). Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes. Genes Dev. 19(8): 891--896. (Export to RIS)
FlyBase ID	FBrf0187596
Publication Type	Research paper
PubMed ID	15833915
PubMed Abstract	From insects to mammals, metallothionein genes are induced in response to heavy metal load by the transcription factor MTF-1, which binds to short DNA sequence motifs, termed metal response elements (MREs). Here we describe a novel and seemingly paradoxical role for MTF-1 in Drosophila in that it also mediates transcriptional activation of Ctr1B, a copper importer, upon copper depletion. Activation depends on the same type of MRE motifs in the upstream region of the Ctr1B gene as are normally required for metal induction. Thus, a single transcription factor, MTF-1, plays a direct role in both copper detoxification and acquisition by inducing the expression of metallothioneins and of a copper importer, respectively.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Alleles (14)
	Avic\GFP^{EYFP.Ctr1B-4MRE.hs} Avic\GFP^{EYFP.Ctr1B-4xMRE1.hs} Avic\GFP^{EYFP.MtnB-4MRE.hs} Ctr1B^3-4 Ctr1B^11-19 Ctr1B^{AH1.T:Avic\GFP-EGFP} Ctr1B^{AH2.T:Avic\GFP-EGFP} Ctr1B^{AH3.T:Avic\GFP-EGFP} Ctr1B^{m1-2-3-4.T:Avic\GFP-EGFP} Ctr1B^{m1-m2-3-4.T:Avic\GFP-EGFP} Ctr1B^{m1-m2-m3-m4.T:Avic\GFP-EGFP} Ctr1B^Scer\UAS.cSa MTF-1^140-1R Scer\GAL4^Act5C.PU
Constructs (10)
	P{Ctr1B-EGFP.AH1} P{Ctr1B-EGFP.AH2} P{Ctr1B-EGFP.AH3} P{Ctr1B-EGFP.m1-2-3-4} P{Ctr1B-EGFP.m1-m2-3-4} P{Ctr1B-mMRE1-mMRE2-mMRE3-mMRE4.EGFP} P{hs.Ctr1B-4MRE-EYFP.S} P{hs.Ctr1B-4xMRE1-EYFP.S} P{hs.MtnB-4MRE-EYFP.S} P{UAS-Ctr1B.S}
Genes (14)
	Avic\GFP Ctr1A Ctr1B Ctr1C Hsp70Aa Hsp70Ab Hsp70Ba Hsp70Bb Hsp70Bbb Hsp70Bc MTF-1 MtnA MtnB Scer\GAL4
Natural transposons (1)
	P-element