Reference Report

Reference
Citation	Bokel, C., Schwabedissen, A., Entchev, E., Renaud, O., Gonzalez-Gaitan, M. (2006). Sara endosomes and the maintenance of Dpp signaling levels across mitosis. Science 314(5802): 1135--1139. (Export to RIS)
FlyBase ID	FBrf0194795
Publication Type	Research paper
PubMed ID	17110576
PubMed Abstract	During development, cells acquire positional information by reading the concentration of morphogens. In the developing fly wing, a gradient of the transforming growth factor-beta (TGF-beta)-type morphogen decapentaplegic (Dpp) is transduced into a gradient of concentration of the phosphorylated form of the R-Smad transcription factor Mad. The endosomal protein Sara (Smad anchor for receptor activation) recruits R-Smads for phosphorylation by the type I TGF-beta receptor. We found that Sara, Dpp, and its type I receptor Thickveins were targeted to a subpopulation of apical endosomes in the developing wing epithelial cells. During mitosis, the Sara endosomes and the receptors therein associated with the spindle machinery to segregate into the two daughter cells. Daughter cells thereby inherited equal amounts of signaling molecules and thus retained the Dpp signaling levels of the mother cell.
DOI	10.1126/science.1132524
Related Publication(s)
Supplementary material	Supporting online material. [FBrf0200011]
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Science
Title	Science
Publication Year	1895-
ISBN/ISSN	0036-8075
Data from Reference
Aberrations (2)
	Df(2R)PK1 Df(2R)Sara¹²
Alleles (6)
	dpp^{Scer\UAS.E.T:Avic\GFP-EGFP} Sara¹ Sara¹² Sara^{Scer\UAS.T:Avic\GFP} Sdc¹² tkv^{Scer\UAS.D.T:Avic\GFP-EGFP}
Constructs (3)
	P{UAS-dpp.GFP.E} P{UAS-Sara.GFP} P{UAS-tkv-EGFP.D}
Genes (9)
	dpp Fas3 Fkbp13 Mad pav Rab5 Sara Sdc tkv
Insertions (1)
	P{EPgy2}Sdc^EY04602