Reference Report

Reference
Citation	Young, J.M., Armstrong, J.D. (2010). Building the central complex in Drosophila: The generation and development of distinct neural subsets. J. Comp. Neurol. 518(9): 1525--1541. (Export to RIS)
FlyBase ID	FBrf0210156
Publication Type	Research paper
PubMed ID	20187144
PubMed Abstract	The distinctive midline neuropil, the central complex (CX), is one of the most prominent features of the insect brain. We investigated the development of the four CX structures and several sets of CX neurons in the Drosophila brain using immunostaining for two cell adhesion molecules, DN-cadherin and Echinoid, and a set of seven enhancer trap lines. Our results showed that the CX is first identifiable in the third instar larva and that it elaborates over the first 48 hours of metamorphosis. The first identifiable structures to appear in their immature form are the protocerebral bridge and fan-shaped body, which are present in the brain of the third instar larva, followed by the noduli (from P12h), and finally the ellipsoid body (from P24h). We observed that neurons are added incrementally to the developing CX structure, with sets of small-field neurons projecting to the CX prior to the large-field neurons. The small-field neurons first project to the developing fan-shaped body, before arborizing or extending to the other structures. We found evidence to suggest that small-field neurons exist in sets of 16 and that they originate from eight common clusters of perikarya in the cortex, suggesting a common origin. We also identified a novel set of pontine neurons that connect contralateral segments in the fan-shaped body.
DOI	10.1002/cne.22285
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Comp. Neurol.
Title	Journal of Comparative Neurology
Publication Year	1911-
ISBN/ISSN	0021-9967
Data from Reference
Alleles (13)
	Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^52y Scer\GAL4^62y Scer\GAL4^71y Scer\GAL4^104Y Scer\GAL4^210Y Scer\GAL4^Aph-4-c232 Scer\GAL4^C5 Scer\GAL4^c61 Scer\GAL4^c159b Scer\GAL4^c255 Scer\GAL4^c465 Scer\GAL4^NP2320
Constructs (1)
	P{UAS-mCD8::GFP.L}
Genes (5)
	Aph-4 CadN ed Mmus\Cd8a Scer\GAL4
Insertions (12)
	P{GawB}52y P{GawB}62y P{GawB}71y P{GawB}104y P{GawB}210Y P{GawB}Aph-4^c232 P{GawB}C5^C5 P{GawB}c61 P{GawB}c159b P{GawB}c465 P{GawB}NP2320 P{GawB}RasGAP1^c255
Transcripts (12)
	Scer\GAL4^52yRA Scer\GAL4^62yRA Scer\GAL4^71yRA Scer\GAL4^104YRA Scer\GAL4^210YRA Scer\GAL4^Aph-4-c232RA Scer\GAL4^C5RA Scer\GAL4^c61RA Scer\GAL4^c159bRA Scer\GAL4^c255RA Scer\GAL4^c465RA Scer\GAL4^NP2320RA