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Reference
Citation
Dourlen, P., Bertin, B., Chatelain, G., Robin, M., Napoletano, F., Roux, M.J., Mollereau, B. (2012). Drosophila Fatty Acid transport protein regulates rhodopsin-1 metabolism and is required for photoreceptor neuron survival.  PLoS Genet. 8(7): e1002833.
FlyBase ID
FBrf0219056
Publication Type
Research paper
Abstract
Tight regulation of the visual response is essential for photoreceptor function and survival. Visual response dysregulation often leads to photoreceptor cell degeneration, but the causes of such cell death are not well understood. In this study, we investigated a fatty acid transport protein (fatp) null mutation that caused adult-onset and progressive photoreceptor cell death. Consistent with fatp having a role in the retina, we showed that fatp is expressed in adult photoreceptors and accessory cells and that its re-expression in photoreceptors rescued photoreceptor viability in fatp mutants. The visual response in young fatp-mutant flies was abnormal with elevated electroretinogram amplitudes associated with high levels of Rhodopsin-1 (Rh1). Reducing Rh1 levels in rh1 mutants or depriving flies of vitamin A rescued photoreceptor cell death in fatp mutant flies. Our results indicate that fatp promotes photoreceptor survival by regulating Rh1 abundance.
PubMed ID
PubMed Central ID
PMC3405995 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS Genet.
    Title
    PLoS Genetics
    Publication Year
    2005-
    ISBN/ISSN
    1553-7404 1553-7390
    Data From Reference
    Alleles (11)
    Genes (5)
    Natural transposons (1)
    Experimental Tools (1)
    Transgenic Constructs (7)
    Transcripts (1)