FB2026_02 , released June 18, 2026
Aberration: Dmel\Df(3R)98E2
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General Information
Symbol
Df(3R)98E2
Species
D. melanogaster
Name
FlyBase ID
FBab0046230
Feature type
chromosomal_deletion
Also Known As
Df(98E2)
Computed Breakpoints include
Features within 98E1--98E2 (Estimated cytology)
Genomic Maps
Sequence coordinates
3R:28,675,020..28,675,020 (Df(3R)98E2:bk1)
(Demontis and Dahmann, 2009, Zhang et al., 2009)
3R:28,730,077..28,730,077 (Df(3R)98E2:bk2)
(Demontis and Dahmann, 2009, Zhang et al., 2009)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
PBac{WH}httf05417
(Zhang et al., 2009)
P{XP}d08071
(Zhang et al., 2009)
Mutagen
FLPase
(Zhang et al., 2009)
Class of aberration (relative to wild type)
chromosomal_deletion
(Zhang et al., 2009)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Zhang et al., 2009)
Breakpoints
Causes alleles
htt98E2
(White et al., 2020, Zhang et al., 2009)
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments

Estimated site of P{XP}d08071 insertion.

(Demontis and Dahmann, 2009, Ricardo and Lehmann, 2009, Zhang et al., 2009)

Recombination between the two progenitor insertions has resulted in deletion of the intervening sequence, which deletes the snu gene and 34kb of the 38kb genomic coding region for htt (only the last two exons remain).

(Zhang et al., 2009)
Comments on Cytology
Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
htt
(Zhang et al., 2009)
snu
(Zuber et al., 2018, Zhang et al., 2009)
Partially deleted / disrupted
Molecular Data
Completely deleted
snu
(Zhang et al., 2009)
Partially deleted
htt
(Zhang et al., 2009)
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (2)
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations

Ready-to-hatch Df(3R)98E2 homozygous larvae are translucid, and both their head skeleton and their ventral denticles are pale; when manually free from the egg case, the larvae dehydrate much faster than controls.

Mutant larvae exhibit a defective cuticle, as shown by cuticle retraction (and consequent shorter larvae) in cuticle preparations, excessive permeability to Eosin Y, severely decreased autofluorescence upon exposure to 405nm light, and reduced cuticulin layer, as shown by both a severely decreased argentaffin staining, and a severely decreased integument Sudan black staining, as compared to controls. At the ultrastructure level, the cuticle shows a cuticulin layer composed of only three sublayers (instead of the five observed in controls) and epicuticle and procuticle layers detach from each other at apodemes (despite of their apparently normal structures).

(Zuber et al., 2018)

Homozygous embryonic lethal.

(Zhang et al., 2009)
Stocks (0)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (7)
Reported As
Symbol Synonym
Df(3R)98E2
Df(93E2)
(Weiss and Littleton, 2016)
Df(98E2)
(Krzystek et al., 2023, White et al., 2020, Zhang et al., 2009)
Df-htt
(Marquilly et al., 2021)
htt-KO
(Krzystek et al., 2023)
snuDf(98E2)
(Zuber et al., 2018)
snuDf
(Zuber et al., 2018)
Name Synonyms
Secondary FlyBase IDs
    References (6)