FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Aberration: Dmel\Df(3R)mthl5-AD5
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General Information
Symbol
Df(3R)mthl5-AD5
Species
D. melanogaster
Name
FlyBase ID
FBab0048091
Feature type
chromosomal_deletion
Computed Breakpoints include
Features within 87A1--87A1 (Estimated cytology)
Genomic Maps
Sequence coordinates
3R:11,882,475..11,882,475 (Df(3R)mthl5-AD5:bk1)
(Patel et al., 2016)
3R:11,887,183..11,887,183 (Df(3R)mthl5-AD5:bk2)
(Patel et al., 2016)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
PBac{WH}CG6962f05936
(Patel et al., 2016)
P{XP}salsad01944
(Patel et al., 2016)
Mutagen
FLPase
(Patel et al., 2016)
Class of aberration (relative to wild type)
chromosomal_deletion
(Patel et al., 2016)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Patel et al., 2016)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments

FLP-mediated recombination between the two progenitor insertions has resulted in the deletion of the genomic sequence between them. The entire coding region of mthl5 along with much of salsa and a portion of the 5' UTR of CG6962 have been deleted.

(Patel et al., 2016)
Comments on Cytology
Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
mthl5
(Patel et al., 2016)
Partially deleted
CG6962
(Patel et al., 2016)
salsa
(Patel et al., 2016)
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (3)
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations

Df(3R)mthl5-AD5/Df(3R)mthl5-AD5 is lethal (all embryos fail to hatch into first instar larvae). Homozygous mutants display significant heart defects, especially with loss of cell-to-cell adhesion between cardioblasts and pericardial cells. Df(3R)mthl5-AD5/+ also show some dissociation of pericardial cells in embryos at low frequencies. Around a quarter of Df(3R)mthl5-AD5/Df(3R)mthl5-AD5 embryos show misaligned cardioblast cells, resulting in abnormally shaped heart tube lumen.

(Patel et al., 2016)
Stocks (0)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Df(3R)mthl5-AD5
GiaAD5
(Patel et al., 2016)
Name Synonyms
Secondary FlyBase IDs
    References (1)