FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Gene: Dmel\mthl5
Open Close
General Information
Symbol
Dmel\mthl5
Species
D. melanogaster
Name
methuselah-like 5
Annotation Symbol
CG6965
Feature Type
protein_coding_gene
FlyBase ID
FBgn0037960
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Summary
methuselah-like 5 (mthl5) encodes a G protein-coupled receptor involved in heart morphogenesis. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
87A1-87A1
Sequence location
Recombination map
3-51
RefSeq locus
NT_033777 REGION:11883938..11887168
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables G protein-coupled receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000947192
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with FLYBASE:mth; FB:FBgn0023000
(Gene Ontology Curators, 2002-)
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
inferred from electronic annotation with InterPro:IPR000832
(InterPro Project Members, 2004-)
enables transmembrane signaling receptor activity
inferred from electronic annotation with InterPro:IPR017981
(InterPro Project Members, 2004-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in heart morphogenesis
inferred from mutant phenotype
(Patel et al., 2016)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in cell surface receptor signaling pathway
inferred from electronic annotation with InterPro:IPR017981
(InterPro Project Members, 2004-)
involved_in determination of adult lifespan
inferred from sequence or structural similarity with UniProtKB:O97148
(Gene Ontology Curators, 2002-)
involved_in G protein-coupled receptor signaling pathway
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
inferred from biological aspect of ancestor with PANTHER:PTN000947192
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with FLYBASE:mth; FB:FBgn0023000
(Gene Ontology Curators, 2002-)
inferred from electronic annotation with InterPro:IPR000832
(InterPro Project Members, 2004-)
involved_in response to starvation
inferred from sequence or structural similarity with UniProtKB:O97148
(Gene Ontology Curators, 2002-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in membrane
inferred from electronic annotation with InterPro:IPR000832, InterPro:IPR017981
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
inferred from sequence or structural similarity with FLYBASE:mth; FB:FBgn0023000
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the G-protein coupled receptor 2 family. Mth subfamily. (Q9VGG8)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
methuselah-like 5 (mthl5) encodes a G protein-coupled receptor involved in heart morphogenesis. [Date last reviewed: 2019-07-11]
Gene Group (FlyBase)
METHUSELAH-TYPE RECEPTORS -
Methuselah GPCRs are Class B GPCRs, forming the B3 subgroup. The gene family's founding member methuselah (mth) was identified as a Drosophila GPCR involved in the modulation of life span and stress response. No counterpart for the methuselah gene family have been identified in vertebrates. (Adapted from FBrf0129744 and FBrf0218628).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\mthl5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VGG8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.49

Gene model reviewed during 5.53

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
mthl5-RA
FBtr0082515
NM_141869
1949
496
mthl5-RB
FBtr0344288
NM_001300362
1952
497
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
mthl5-PA
FBpp0081989
56.4
496
6.91
Q9VGG8
NP_650126
AAF54714
mthl5-PB
FBpp0310692
56.4
497
6.91
A0A0B4LH68
NP_001287291
AHN57290
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mthl5 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.39

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
central brain primordium
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
cardiogenic mesoderm
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
dorsal vessel primordium

Comment: reported as dorsal vessel specific anlage

(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
salivary gland body primordium

Comment: reported as salivary gland primordium

(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13
embryonic cardioblast
(Patel et al., 2012)
cardiogenic mesoderm
(Patel et al., 2012)
visceral trunk mesoderm
(Patel et al., 2012)
embryonic stage 13 -- 15
embryonic heart cardioblast
(Patel et al., 2016)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
larval circulatory system
(Fisher et al., 2012)
embryonic/larval dorsal vessel
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral imaginal tissue
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic aortic cardioblast
(Patel et al., 2016)
embryonic stage 16
embryonic/larval dorsal vessel | anterior
(Patel et al., 2012)
Additional Descriptive Data

mthl5 expression becomes stronger in the aorta cardioblasts and weaker in the heart cardioblasts from stage 13 to stage 15. mthl5 expression becomes restricted to aorta

(Patel et al., 2016)

cardioblasts at stage 15 and remains highly specific to aorta cardioblasts at stage 16.

(Patel et al., 2016)

mthl5 expression is observed in the visceral and cardiac mesoderm with specific expression in the cardioblasts and dorsal muscles, but finally restricted to the dorsal vessel.

(Patel et al., 2012)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
wing disc | ubiquitous
(Saad and Hipfner, 2021)
Additional Descriptive Data

mthl5 protein is distributed ubiquitously in wing discs. The protein accumulates preferentially in the apical region of cells.

(Saad and Hipfner, 2021)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mthl5 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mthl5
Transgenic constructs containing regulatory region of mthl5
Aberrations (Deficiencies and Duplications) ( 1 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (32)
Hsap\ADGRD1
2 of 14
Yes
Yes
Hsap\ADGRD2
2 of 14
Yes
No
Hsap\ADGRE1
2 of 14
Yes
No
Hsap\ADGRE2
2 of 14
Yes
No
Hsap\ADGRE3
2 of 14
Yes
No
Hsap\ADGRE5
2 of 14
Yes
No
Hsap\ADGRF3
2 of 14
Yes
Yes
Hsap\ADGRF4
2 of 14
Yes
Yes
Hsap\ADGRF5
2 of 14
Yes
Yes
Hsap\ADGRG2
2 of 14
Yes
No
Hsap\ADGRG3
2 of 14
Yes
No
Hsap\ADGRG4
2 of 14
Yes
No
Hsap\ADGRG6
2 of 14
Yes
No
Hsap\ADGRG7
2 of 14
Yes
No
Hsap\ADGRL1
2 of 14
Yes
No
Hsap\ADGRL2
2 of 14
Yes
No
Hsap\ADGRL3
2 of 14
Yes
No
Hsap\ADGRL4
2 of 14
Yes
No
Hsap\ADGRB1
1 of 14
No
No
Hsap\ADGRB2
1 of 14
No
No
Hsap\ADGRB3
1 of 14
No
No
Hsap\ADGRE4P
1 of 14
No
No
Hsap\ADGRF1
1 of 14
No
No
Hsap\ADGRF2
1 of 14
No
No
Hsap\ADGRG1
1 of 14
No
No
Hsap\ADGRG5
1 of 14
No
No
Hsap\ADGRV1
1 of 14
No
No
Hsap\CALCR
1 of 14
No
No
Hsap\CELSR1
1 of 14
No
No
Hsap\CELSR2
1 of 14
No
No
Hsap\GPR143
1 of 14
No
Yes
Hsap\MTNR1B
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (24)
Rnor\Adgrd1
2 of 14
Yes
Yes
Rnor\Adgre1
2 of 14
Yes
No
Rnor\Adgre5
2 of 14
Yes
No
Rnor\Adgrf3
2 of 14
Yes
Yes
Rnor\Adgrf4
2 of 14
Yes
Yes
Rnor\Adgrf5
2 of 14
Yes
Yes
Rnor\Adgrg2
2 of 14
Yes
No
Rnor\Adgrg3
2 of 14
Yes
No
Rnor\Adgrg6
2 of 14
Yes
No
Rnor\Adgrg7
2 of 14
Yes
No
Rnor\Adgrl2
2 of 14
Yes
No
Rnor\Adgra3
1 of 14
No
No
Rnor\Adgrb1
1 of 14
No
No
Rnor\Adgrb2
1 of 14
No
No
Rnor\Adgrb3
1 of 14
No
No
Rnor\Adgre4
1 of 14
No
Yes
Rnor\Adgrf2
1 of 14
No
Yes
Rnor\Adgrg5
1 of 14
No
No
Rnor\Adgrl1
1 of 14
No
No
Rnor\Adgrl3
1 of 14
No
No
Rnor\Adgrl4
1 of 14
No
No
Rnor\Adgrv1
1 of 14
No
Yes
Rnor\Celsr2
1 of 14
No
No
Rnor\Celsr3
1 of 14
No
No
Mus musculus (laboratory mouse) (27)
Mmus\Adgre1
2 of 14
Yes
No
Mmus\Adgre4
2 of 14
Yes
Yes
Mmus\Adgre5
2 of 14
Yes
Yes
Mmus\Adgrf2
2 of 14
Yes
Yes
Mmus\Adgrf3
2 of 14
Yes
Yes
Mmus\Adgrf4
2 of 14
Yes
Yes
Mmus\Adgrf5
2 of 14
Yes
Yes
Mmus\Adgrg1
2 of 14
Yes
No
Mmus\Adgrg2
2 of 14
Yes
No
Mmus\Adgrg3
2 of 14
Yes
No
Mmus\Adgrg6
2 of 14
Yes
No
Mmus\Adgrl1
2 of 14
Yes
No
Mmus\Adgrl3
2 of 14
Yes
No
Mmus\Adgrl4
2 of 14
Yes
No
Mmus\Adgrb1
1 of 14
No
No
Mmus\Adgrb2
1 of 14
No
No
Mmus\Adgrb3
1 of 14
No
No
Mmus\Adgrd1
1 of 14
No
No
Mmus\Adgrf1
1 of 14
No
No
Mmus\Adgrg4
1 of 14
No
No
Mmus\Adgrg5
1 of 14
No
No
Mmus\Adgrg7
1 of 14
No
No
Mmus\Adgrl2
1 of 14
No
No
Mmus\Calcr
1 of 14
No
No
Mmus\Celsr2
1 of 14
No
No
Mmus\Celsr3
1 of 14
No
No
Mmus\Taar4
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (7)
Xtro\lgmn
2 of 13
Yes
No
Xtro\adgrd2
1 of 13
No
No
Xtro\celsr3
1 of 13
No
No
Xtro\dnai2
1 of 13
No
No
Xtro\fzd6
1 of 13
No
No
Xtro\mturn
1 of 13
No
Yes
Xtro\rab15
1 of 13
No
Yes
Danio rerio (Zebrafish) (38)
Drer\adgre9
2 of 14
Yes
No
Drer\adgre10
2 of 14
Yes
No
Drer\adgre14
2 of 14
Yes
No
Drer\adgre15
2 of 14
Yes
No
Drer\adgrf3a
2 of 14
Yes
Yes
Drer\adgrf8
2 of 14
Yes
No
Drer\adgrf11
2 of 14
Yes
Yes
Drer\adgrg2a
2 of 14
Yes
No
Drer\adgrg3
2 of 14
Yes
No
Drer\adgrg6
2 of 14
Yes
No
Drer\adgrl1a
2 of 14
Yes
No
Drer\adgrl2a
2 of 14
Yes
No
Drer\adgrl4
2 of 14
Yes
No
Drer\adgrb1a
1 of 14
No
No
Drer\adgrb1b
1 of 14
No
Yes
Drer\adgrb3
1 of 14
No
Yes
Drer\adgrd1
1 of 14
No
Yes
Drer\adgrd2
1 of 14
No
No
Drer\adgre5b.2
1 of 14
No
No
Drer\adgre5b.3
1 of 14
No
No
Drer\adgre16
1 of 14
No
Yes
Drer\adgrf3b
1 of 14
No
No
Drer\adgrf6
1 of 14
No
Yes
Drer\adgrf7
1 of 14
No
Yes
Drer\adgrg1
1 of 14
No
No
Drer\adgrg4a
1 of 14
No
No
Drer\adgrg11
1 of 14
No
No
Drer\adgrl2b.1
1 of 14
No
No
Drer\adgrl3.1
1 of 14
No
No
Drer\adgrv1
1 of 14
No
No
Drer\celsr1a
1 of 14
No
No
Drer\celsr1b
1 of 14
No
No
Drer\celsr2
1 of 14
No
No
Drer\celsr3
1 of 14
No
No
Drer\LOC100331278
1 of 14
No
No
Drer\LOC100536657
1 of 14
No
Yes
Drer\LOC100538283
1 of 14
No
No
Drer\LOC103909395
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\lat-1
1 of 14
Yes
No
Cele\lat-2
1 of 14
Yes
No
Cele\ser-7
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (11)
Agam\GPRMTH5
10 of 12
Yes
Yes
Agam\AgaP_AGAP000130
2 of 12
No
No
Agam\GPRMTH1
2 of 12
No
No
Agam\GPRMTH3
2 of 12
No
No
Agam\GPRCIR
1 of 12
No
No
Agam\GPRDIH2
1 of 12
No
No
Agam\GPRMTH2
1 of 12
No
No
Agam\GPRMTH4
1 of 12
No
No
Agam\GPRMTH6
1 of 12
No
No
Agam\GPRMTHL7
1 of 12
No
No
Agam\GPRSTN
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:mthl5. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (22)
mthl1
3 of 13
Mayo
2 of 13
mthl2
2 of 13
mthl3
2 of 13
mthl4
2 of 13
mthl6
2 of 13
mthl7
2 of 13
mthl11
2 of 13
mthl12
2 of 13
mthl13
2 of 13
mthl14
2 of 13
mth
2 of 13
CG43968
1 of 13
Cirl
1 of 13
Dh44-R1
1 of 13
Dh44-R2
1 of 13
fz
1 of 13
Ktch
1 of 13
mthl8
1 of 13
mthl9
1 of 13
mthl10
1 of 13
mthl15
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    mthl5 - Gαo
    anti tag coimmunoprecipitation, anti tag western blot
    (Patel et al., 2016)
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    mthl5
    suppressible
    Pka-C1
    (Saad and Hipfner, 2021)
    mthl5
    suppressible
    tkv
    (Saad and Hipfner, 2021)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-51
    Cytogenetic map
    87A1-87A1
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    87A1-87A1
    Limits computationally determined from genome sequence between P{EP}Lk6EP886 and P{PZ}svp07842
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-51

    (FlyBase, 2016)

    3-48.9

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (9)
    Genomic Clones (22)
    cDNA Clones (35)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Saad and Hipfner, 2021)
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments
        Relationship to Other Genes
        Source for database merge of

        Source for merge of: mthl5 anon-WO0170980.71 anon-WO0170980.70

        (FlyBase, 1996-)
        Additional comments

        Source for merge of mthl5 anon-WO0170980.71 anon-WO0170980.70 was sequence comparison ( date:051113 ).

        (FlyBase, 1996-)
        Nomenclature History
        Source for database identify of
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (13)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 37 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        MIST (protein-protein) - An integrated Molecular Interaction Database
        References (58)