loss of function allele

An eight-base-pair deletion in the sc coding region it produces a polypeptide containing the first 114 amino acids of the sc translation product followed by 53 nonsense amino acids; the truncated polypeptide retains the basic region but not the helices of the helix-loop-helix motif. 8 bp deletion that creates a frameshift and a shortened polypeptide that is most likely inactive.

Revertant.

Elevated transcription of l(1)sc and ac observed in In(1)Hw^49c is abolished.