FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Act88F5
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General Information
Symbol
Dmel\Act88F5
Species
D. melanogaster
Name
FlyBase ID
FBal0000271
Feature type
allele
Associated gene
Dmel\Act88F
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Fyrberg et al., 1988)

hypomorphic allele - genetic evidence

(An and Mogami, 1996)
Mutagen
ethyl methanesulfonate
(An and Mogami, 1996)
Progenitor genotype
Cytology
Description

Amino acid replacement: G366S. Nucleotide substitution: G3912A.

(An and Mogami, 1996)

Amino acid replacement: G366S.

(Fyrberg et al., 1988)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:15,441,775..15,441,775 [+]
Nucleotide change:

G15441775A

Reported nucleotide change:

G3912A

Amino acid change:

G367S | Act88F-PA

Reported amino acid change:

G366S

(An and Mogami, 1996, Fyrberg et al., 1988)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes rarely exhibit free myofibril fibres and if present they are cut, fragmented, torn and gapped. Indirect flight muscle fibres are normal in homozygotes and heterozygotes.

      (An and Mogami, 1996)

      Indirect flight muscle nuclei enlarged and myofibrils disrupted.

      (Hiromi and Hotta, 1985)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Strongly induces heat shock proteins.

      Produces half normal amount of actin isoform III; shows increased synthesis of actin I, normally present in only trace amounts in indirect flight muscle.

      (Hiromi and Hotta, 1985)

      Two mutants isolated.

      (An and Mogami, 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Act88F5
      Act88FHH5
      (Fyrberg et al., 1988)
      G366S
      (Mogami et al., 1998, An and Mogami, 1996)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)