FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Actn9
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General Information
Symbol
Dmel\Actn9
Species
D. melanogaster
Name
FlyBase ID
FBal0000283
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutagen
Progenitor genotype
Caused by aberration
Cytology

Associated with an inversion break; cytology not described.

Description

Codon 254 of the Actn open reading frame is interrupted by DNA of unknown origin.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hemizygous larvae hatch somewhat later than their wild-type counterparts. They appear small and flaccid and move poorly. Shortly after hatching, the larvae move at 60% the rate of their wild-type counterparts, by 24 hours after hatching movement is reduced to 25% of wild type, and by 48 hours after hatching the larvae are immobile. Larval growth does not occur. One day old larvae have muscle defects; large areas where the muscle filaments are disorganised are seen using electron microscopy. Myofibrils are grossly disorganised in older larvae. Rhabdomeres within homozygous clones in the eye appear normal in size, density and morphology.

Phenotype of homozygous germ line clones demonstrates is there is no maternal effect.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Lefevre.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
  • FBal0028761
References (5)