FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AdhF
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General Information
Symbol
Dmel\AdhF
Species
D. melanogaster
Name
Fast
FlyBase ID
FBal0000314
Feature type
allele
Associated gene
Dmel\Adh
Associated Insertion(s)
Carried in Construct
Also Known As
F, Adh-F
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
natural population
(Parkash et al., 1993, Kreitman, 1983)
Progenitor genotype
Cytology
Description

Mutation is relative to AdhS, coordinates according to FBrf0054162.

(Kelly, 1997)

Nucleotide substitution: A1490C.

(Kelly, 1997)

Amino acid replacement: K192T.

(Eisses et al., 1990)

2 length polymorphisms exist. One in the adult intron between nucleotides 447 and 477, a 34bp insertion of a tandemly repeated unit associated with a 29bp deletion so net increase is 5 bp. The second length polymorphism is 37bp inserted at nucleotide position 550-551.

(Kreitman, 1983)

Amino acid replacement: K192T. Nucleotide substitution: A713C.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Oviposition sites on standard medium and acetic acid supplement medium are studied.

      (Eisses, 1997)

      If reared at 25oC homozygotes died at 35oC. Flies reared at 29oC showed less significant differences in survival between genotypes than flies reared at 20oC and 25oC.

      (Oudman et al., 1992)

      Egg to adult developmental time of Adh genotypes depends on the Gpdh genotype and temperature. Homozygotes demonstrate fast development with all Gpdh genotypes, the AdhF/AdhS heterozygote shows an intermediate rate between the homozygotes. Adult weight of Adh genotypes is not affected by temperature or Gpdh genotype: Adh heterozygote is significantly heavier than the homozygotes, which have a similar weight.

      (Oudman et al., 1991)

      Adh+ flies exhibit a higher sensitivity to pentenol than Adh- flies but a similar sensitivity to pentenone. Homozygous AdhF and homozygous Resistant to ethanol, sensitive to pentenol.

      (Garrido and Barbancho, 1990)

      Flies carrying AdhF have a selective advantage under conditions of alcohol stress. AdhF/AdhS flies are more resistant to the effect of high temperature.

      (Totskii et al., 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
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      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (8)
      Notes on Origin
      Discoverer

      Johnson and Denniston.

      Comments
      Comments

      pI of protein: 6.4.

      The frequency of AdhF in a wine cellar was higher than AdhS. Statistical analysis demonstrates a significant increase of AdhF inside the cellar with respect to outside, and the converse situation for AdhS.

      (Wallace, 1984)

      The analysis of within and between species polymorphism has shown a balanced polymorphism near position 1490, the site of the amino acid replacement difference (lys to thr) between AdhF and AdhS. The pattern of silent polymorphisms in the coding region can be explained by the presence of the single balanced polymorphism.

      (Kreitman and Hudson, 1991)

      AdhF homozygote and the AdhF/AdhS heterozygote have a high adult male protein content within the temperature range analysed. The Adh heterozygote has a significantly lower triglyceride content than the homozygotes which have a similar higher content, the values varied slightly in different Gpdh genotypes and temperatures. At all the temperatures ADH activity in AdhF homozygotes is high in all Gpdh genotypes and the Adh heterozygote ADH activity is intermediate between the homozygotes.

      (Oudman et al., 1991)

      This allele fixed in lines selected for low geotaxis.

      (Stoltenberg et al., 1992)

      Protein content, triglyceride content and ADH enzyme activity decreased significantly at 35oC, no correlation was observed between survival and these traits.

      (Oudman et al., 1992)

      AdhF and AdhS lines were isolated from Chinese and Australian populations. Average Adh protein activity was higher in Chinese than Australian populations for AdhF and AdhS lines. There is a significant correlation between Adh protein activity and Adh protein levels. AdhF lines had more CRM than AdhS lines.

      (Jiang and Gibson, 1992)

      Homozygotes have increased specific activities of Mdh1, Gpdh, Pgm, Idh, Me and Gapdh1 gene products. The differences between the enzyme quantities in AdhF homozygotes and AdhS homozygotes segregate as if caused by a single Mendelian gene with codominant alleles.

      (Li, 1992)

      Gramoxone increases the frequency of the AdhS allele and decreases the frequency of the AdhF allele in the offspring of treated flies.

      (el Abidin Salam et al., 1993)

      Lines of flies selected for increased ethanol or acetic acid tolerance show an increase in the frequency of the AdhF allozyme within the line.

      (Chakir et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      References (121)