FlyBase Allele Report: Dmel\amd[11]

General Information

Symbol

Dmel\amd¹¹

Species

D. melanogaster

Name

FlyBase ID

FBal0000468

Feature type

allele

Associated gene

Dmel\amd

Associated Insertion(s)

Carried in Construct

Also Known As

l(2)amd^H149, amd^H149

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Wright et al., 1982, Wright et al., 1976)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical sensitive | dominant

(Wright et al., 1982)

chemical sensitive | recessive

(Wright et al., 1976)

lethal (with Df(2L)TW130)

(McCrady and Tolin, 1994)

lethal | recessive

(Wright et al., 1982)

partially lethal (with amd¹)

(Bishop et al., 1999)

partially lethal (with amd^H29)

(Bishop et al., 1999)

Phenotype Manifest In

cuticle

(Wright et al., 1982)

Detailed Description

Statement

Reference

Hemizygous amd¹¹/Df(2L)TW130 animals do not survive to late third larval instar.

(McCrady and Tolin, 1994)

Dominantly hypersensitive to dietary α-methyl dopa. Lethality is at the egg/larval boundary effective lethal phase. Cuticle incompletely sclerotinized and fragile. Sensitive to α-methyl dopa.

(Wright et al., 1982)

α-MD hypersensitive.

(Wright et al., 1976)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

amd¹¹/amd^H29 has partially lethal phenotype, suppressible by Tcr⁴⁵

(Bishop et al., 1999)

amd¹/amd¹¹ has partially lethal phenotype, suppressible by Df(3L)TP32

(Bishop et al., 1999)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

amd^H29/amd¹¹ transheterozygotes show partial lethality. These flies show a striking increase in viability if they are also carrying one copy of Tcr⁴⁵. amd¹/amd¹¹ transheterozygotes show partial lethality. These flies show a substantial increase in viability if they are also carrying one copy of Df(3L)TP32.

(Bishop et al., 1999)

amd¹¹/amd¹ flies show an increase in viability when they are also heterozygous for Tcr⁴⁰.

(Bishop et al., 1989)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Shows intragenic complementation with other amd alleles.

(Wright et al., 1982)

Alleles of amd show intracistronic complementation.

(Wright et al., 1976)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Wright.

Selected as: Recessive lethal.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

amd¹¹

amd^H149

(McCrady and Tolin, 1994, Wright et al., 1976)

l(2)amd^H149

(Bishop et al., 1999, Bishop et al., 1989, Wright et al., 1982)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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