FlyBase Allele Report: Dmel\arm[2a9]

General Information

Symbol

Dmel\arm^2a9

Species

D. melanogaster

Name

FlyBase ID

FBal0000717

Feature type

allele

Associated gene

Dmel\arm

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Peifer et al., 1993, Peifer and Wieschaus, 1990)

Mutagen

X ray

(Peifer and Wieschaus, 1990)

Progenitor genotype

Cytology

Description

8 bp deletion, ATCCCGGC, and a 4 bp insertion, GTGT at nucleotides 2542--2549.

(Peifer and Wieschaus, 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

X:1,896,045..1,896,052 [-]

Comment:

8 bp deletion, ATCCCGGC, and a 4 bp insertion, GTGT.

Inserted_sequence:

GTGT

(Peifer and Wieschaus, 1990)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage

(Valenta et al., 2011, Peifer and Wieschaus, 1990)

segment polarity phenotype

(Peifer and Wieschaus, 1990)

segment polarity phenotype | embryonic stage

(Peifer and Wieschaus, 1990)

some die during embryonic stage

(Valenta et al., 2011, Peifer and Wieschaus, 1990)

Phenotype Manifest In

denticle | ectopic, with arm^{D164A.αTub84B.Tag:MYC}

(Hoffmans and Basler, 2004)

embryo

(Peifer and Wieschaus, 1990)

embryo | dorsal closure stage

(Peifer and Wieschaus, 1990)

embryonic/first instar larval cuticle, with arm^{D164A.αTub84B.Tag:MYC}

(Hoffmans and Basler, 2004)

embryonic/first instar larval cuticle | dorsal

(Peifer and Wieschaus, 1990)

Detailed Description

Statement

Reference

Hemizygous arm^2a9 mutants die as embryos.

(Valenta et al., 2011)

Embryos fail to close dorsally and much of the dorsal cuticle is missing. Segments are still recognizable but their segment polarity phenotype is very severe.

(Peifer and Wieschaus, 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

arm^2a9 is rescued by arm^αTub84B.PV

(Valenta et al., 2011)

arm^2a9 is rescued by arm^{αTub84B.Tag:MYC}

(Hoffmans and Basler, 2004)

arm^2a9 is rescued by arm^{E163A.αTub84B.Tag:MYC}

(Hoffmans and Basler, 2004)

Partially rescued by

arm^2a9 is partially rescued by arm^ΔC.αTub84B

(Valenta et al., 2011)

Not rescued by

arm^2a9 is not rescued by arm^{D172A.αTub84B}

(Valenta et al., 2011)

arm^2a9 is not rescued by arm^{D172A.ΔC.αTub84B}

(Valenta et al., 2011)

arm^2a9 is not rescued by arm^{D164A.αTub84B.Tag:MYC}

(Hoffmans and Basler, 2004)

arm^2a9 is not rescued by arm^{K435E.αTub84B.Tag:MYC}

(Hoffmans and Basler, 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

arm^2a9

(Valenta et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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