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General Information
Symbol
Dmel\ash110
Species
D. melanogaster
Name
FlyBase ID
FBal0000740
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: A5167T. Amino acid replacement: N1385I.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygous adults display transformation of the fifth abdominal segment towards the likelihood of A5, and frequently show a partial haltere-to-wing transformation.

Few double heterozygotes with Ubxabx-1, trxel2 or brm2 exhibit transformation of third leg to second leg identity and haltere to wing transformation.

Transformation of posterior to anterior wing margin. Homeotic transformations also seen in clones of homozygous cells in otherwise heterozygous flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

ash110 has homeotic phenotype, suppressible by Kdm2KG04325/Kdm2[+]

ash110 has homeotic phenotype, suppressible by Kdm2EY01336/Kdm2[+]

ash110 has homeotic phenotype, suppressible by Kdm2[+]/Kdm2DG12810

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The frequency of homeotic transformations is strikingly reduced in flies transheterozygous for ash110 and Kdm2KG04325, Kdm2EY01336 or Kdm2DG12810, compared to flies heterozygous for ash110 alone.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Range of lethality for transheterozygotes extends from the third larval instar for the most severe alleles to the pharate adult stage for the least severe alleles.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)