FlyBase Allele Report: Dmel\ash1[10]

General Information

Symbol

Dmel\ash1¹⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0000740

Feature type

allele

Associated gene

Dmel\ash1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Tripoulas et al., 1996)

Mutagen

ethyl methanesulfonate

(Tripoulas et al., 1996, Tripoulas et al., 1994)

Progenitor genotype

Cytology

Description

Nucleotide substitution: A5167T. Amino acid replacement: N1385I.

(Tripoulas et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

homeotic

(Lagarou et al., 2008)

lethal | recessive

(Tripoulas et al., 1994)

lethal - all die before end of P-stage | recessive

lethal - all die before end of pupal stage | recessive

(Tripoulas et al., 1996)

some die during pharate adult stage | recessive

some die during pupal stage | recessive

(Tripoulas et al., 1996)

visible | homeotic

Phenotype Manifest In

abdominal segment

(Lagarou et al., 2008)

haltere

(Lagarou et al., 2008)

wing

Detailed Description

Statement

Reference

Heterozygous adults display transformation of the fifth abdominal segment towards the likelihood of A5, and frequently show a partial haltere-to-wing transformation.

(Lagarou et al., 2008)

Few double heterozygotes with Ubx^abx-1, trx^el2 or brm² exhibit transformation of third leg to second leg identity and haltere to wing transformation.

(Tripoulas et al., 1996)

Transformation of posterior to anterior wing margin. Homeotic transformations also seen in clones of homozygous cells in otherwise heterozygous flies.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ash1¹⁰ has homeotic phenotype, suppressible by Kdm2^KG04325/Kdm2[+]

(Lagarou et al., 2008)

ash1¹⁰ has homeotic phenotype, suppressible by Kdm2^EY01336/Kdm2[+]

(Lagarou et al., 2008)

ash1¹⁰ has homeotic phenotype, suppressible by Kdm2[+]/Kdm2^DG12810

(Lagarou et al., 2008)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The frequency of homeotic transformations is strikingly reduced in flies transheterozygous for ash1¹⁰ and Kdm2^KG04325, Kdm2^EY01336 or Kdm2^DG12810, compared to flies heterozygous for ash1¹⁰ alone.

(Lagarou et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ash1²²/ash1¹⁰ is rescued by ash1^{αTub84B.EGFP}

(Steffen et al., 2013)

Df(3L)Exel9011/ash1¹⁰ is rescued by ash1^{αTub84B.EGFP}

(Steffen et al., 2013)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Range of lethality for transheterozygotes extends from the third larval instar for the most severe alleles to the pharate adult stage for the least severe alleles.

(Tripoulas et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

SP1017

ash1¹⁰

(Steffen et al., 2021, Steffen et al., 2013, Lagarou et al., 2008)

dash¹²

(Lindsley and Zimm, 1992)

dash^SP1017

(Shearn et al., 1971)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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