FB2026_02 , released June 18, 2026
Allele: Dmel\aurA1
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General Information
Symbol
Dmel\aurA1
Species
D. melanogaster
Name
FlyBase ID
FBal0000799
Feature type
allele
Associated gene
Dmel\aurA
Associated Insertion(s)
Carried in Construct
Also Known As
aur074-18, aur1
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      aurA1/Df(3R)Exel6162 embryos exhibit severe chromosome mis-segregation defects.

      (Liu et al., 2019)

      rlSu14 and Dsor1Su1 have no effect on the mutant phenotype.

      (Inoue and Glover, 1998)

      Embryos from homozygous mothers show prometaphase nuclei in juxtaposition to paired sets of centrosomes. The paired centrosomes function together as a single pole to nucleate bipolar spindles associated with two groups of condensed chromosomes. Other embryos show more extremely mitotic defects in which spindle structures associated with discrete groups of condensed chromosomes become intricately branched, sharing common centrosomes as microtubule-organizing centers. Free centrosomes that have dissociated from spindles can also be seen in such embryos. Later embryos have many polyploid nuclei. Real time observation reveals example of chromatids being pulled towards the pole of the neighboring spindle, and incomplete anaphase ending with a tetraploid nucleus.

      (Glover et al., 1995)

      Embryos abnormal from nuclear cycle 9 onward; multiple spindles assemble in long arrays with shared centrosomes; polyploid nuclei develop with multiple centrosomes. Hemizygotes pupate but form longer-than-normal pupae.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      References (9)