FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cac1
Open Close
General Information
Symbol
Dmel\cac1
Species
D. melanogaster
Name
cacophony
FlyBase ID
FBal0001506
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
cac
Key Links
Nature of the Allele
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

cac1/Df(1)RC29 females show convulsions and locomotor defects when exposed to 37oC. The convulsion phenotype is characterised by the flies turning upside-down onto their backs or onto their sides for a few seconds. In addition the flies sometimes curl their abdomens severely (either when on their backs or walking), and occasionally the flies spin around. The courtship song parameters interpulse interval, cycles per pulse and amplitude of sound are higher in cac1 males than in wild-type males. The difference in courtship song interpulse interval between cac1 and wild-type males shows a significant negative correlation with temperature.

Aberrant intervals between song pulses. Some pulses, however, are quasi-normal in their cycle numbers; these, as well as many of the polycyclic pulses, have essentially normal intra-pulse frequencies; other pulses exhibit anomalous modulations and these show multiple peaks in the intra-pulse spectra, unlike wild type.

Song mutant. Vision normal (behaviorally and physiologically).

Males court abnormally with poor mating success and aberrant courtship song, which includes pulses of tone that are polycyclic, rather than monocyclic or tricyclic, within wild-type pulses and have increased amplitude. Mating success of wingless mutant males is still worse than that of wingless wild-type males, which is correlated with genetic separability of song abnormalities from deficit in mating performance. Female courtship appears to be unaffected by cac; but general locomotor activity of males or females is subnormal. cac is recessive for generally abnormal behavior and for courtship song defects in tra flies (Kulkarni, Hall and Schilcher).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

mlenap-ts1 seems to enhance the interpulse interval defects of cac1 males, but partly suppresses the cac1 defects in cycles per pulse and amplitude of sound.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Name Synonyms
cacophony
Secondary FlyBase IDs
    References (15)