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General Information
Symbol
Dmel\cact13
Species
D. melanogaster
Name
FlyBase ID
FBal0001519
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
cactPD, cactPD74
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous larvae and adults do not have melanotic capsules.

In the presence of additional dl protein, the mild maternal haploinsufficiency becomes more severe and only 11% of embryos hatch. Females transheterozygous for a cact gain of function allele and a loss of function allele result in embryos in which ventral structures are progressively lost at the expense of dorsal structures as the strength of the loss of function allele increases.

Moderate ventralizing phenotype: dorsal epidermis is replaced by naked epidermis of more lateral positions and sense organs of the head are lost. Expansion of twi expression in terminal regions.

Eggs derived from homozygous females cellularise normally but become abnormal at gastrulation. The cephalic furrow is very deep on the dorsal side during gastrulation and in many cases the germband does not extend at all or moves only a short distance around the posterior pole onto the dorsal side of the egg. Consequently, the posterior midgut invagination forms close to the posterior pole. The dorsal folds do not form and no amnioserosa is apparent. The embryos are ventralised. The ventral denticle belts are expanded laterally and dorsal cuticle elements such as Filzkorper and spiracles are missing. Most of the head structures are absent.

Embryos derived from homozygous females are partially ventralised.

Very strong cact allele.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Overexpression of dl phenocopies the loss of function mutant cact phenotype.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (10)