FB2026_02 , released June 18, 2026
Allele: Dmel\Ten-acbd-KS96
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General Information
Symbol
Dmel\Ten-acbd-KS96
Species
D. melanogaster
Name
FlyBase ID
FBal0001557
Feature type
allele
Associated gene
Dmel\Ten-a
Associated Insertion(s)
Carried in Construct
Also Known As
cbdKS96
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Amino acid replacement: R2846C.

(Cheng et al., 2013)

Mutation points are assigned to the RE transcript, which encodes the largest protein isoform. CGT codon changed to TGT.

(Cheng et al., 2013)

Nucleotide substitution: C?T.

(Cheng et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:12,329,582..12,329,582 [+]
Nucleotide change:

C12329582T

Reported nucleotide change:

C?T

Amino acid change:

R2472C | Ten-a-PD; R2846C | Ten-a-PE; R2472C | Ten-a-PF; R2370C | Ten-a-PG; R2472C | Ten-a-PI; R2472C | Ten-a-PK; R2481C | Ten-a-PL; R2481C | Ten-a-PM; R2472C | Ten-a-PN; R2855C | Ten-a-PO; R2846C | Ten-a-PP

Reported amino acid change:

R2846C

(Cheng et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes and hemizygotes show a disrupted ellipsoid body and fan-shaped body within the central complex of the brain.

      Transheterozygotes with Ten-a900 show a disrupted ellipsoid body and fan-shaped body within the central complex of the brain.

      (Cheng et al., 2013)

      Mutants have impaired visual pattern memory.

      (Liu et al., 2006)

      Mutants show severe disruption of the central complex, including a failure of neuropils from the two hemispheres to fuse at the midline. On either side of the midline, axons form ellipsoid body-like structures which vary widely in shape. In most cases, R4d axons remain within the neuropil mass on the ipsilateral side, but occasionally they appear to cross the midline.

      (Renn et al., 1999)

      Homozygous larvae show reduced locomotor behaviour (shorter path lengths) on agar (non-foraging surface) and yeast (foraging surface) compared to controls. Larvae perform normally in a roll over test.

      (Varnam et al., 1996)

      Abnormal position and internal structure of optic lobes.

      (Strauss and Heisenberg, 1993)

      Central complex is dissociated into two fibre masses of variable shape. β,γ lobes of mushroom bodies are reduced.

      (Heisenberg et al., 1985)

      Entire central complex of brain (with exception of protocerebral bridge) dissociated into two fiber masses of variable shape; some of dorsal brain's mushroom body lobes reduced in size; inter-hemispheric commissure of brain reduced in size (in white pupae); abnormal learning in adult and larvae tests using olfactory stimuli; subnormal locomotor activity.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ten-acbd-KS96
      cbd1
      cbdKS96
      (Cheng et al., 2013, Liu et al., 2006, Renn et al., 1999, Ferrus and Canal, 1994, Heisenberg et al., 1985)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)