FlyBase Allele Report: Dmel\Cdk1[E1-9]

General Information

Symbol

Dmel\Cdk1^E1-9

Species

D. melanogaster

Name

FlyBase ID

FBal0001575

Feature type

allele

Associated gene

Dmel\Cdk1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Clegg et al., 1993, Stern et al., 1993)

Mutagen

ethyl methanesulfonate

(Clegg et al., 1993, Stern et al., 1993)

Progenitor genotype

Cytology

Description

Amino acid replacement: P242S. Nucleotide substitution: C?T.

(Clegg et al., 1993)

Missense mutation: proline replaced by serine in a position that is completely invariant in known cdc2 homologs.

(Stern et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:10,385,012..10,385,012 [-]

Nucleotide change:

C10385012T

Reported nucleotide change:

C?T

Amino acid change:

P242S | Cdk1-PA

Reported amino acid change:

P242S

Comment:

The Cdk1^E1-9 sequence is in GB:S66810.

(Clegg et al., 1993, Stern et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

S66810

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | larval stage

(Stern et al., 1993)

abnormal size | larval stage

(Stern et al., 1993)

lethal | recessive

(Stern et al., 1993)

lethal - all die before end of pupal stage | recessive

(Clegg et al., 1993)

some die during pupal stage | recessive

(Clegg et al., 1993)

Phenotype Manifest In

imaginal disc

(Stern et al., 1993)

imaginal disc | larval stage

(Clegg et al., 1993)

larva

(Stern et al., 1993)

larval brain

(Clegg et al., 1993)

Detailed Description

Statement

Reference

Larvae contain no imaginal discs. Brain development is abnormal.

(Clegg et al., 1993)

Die after pupariation at the larval-pupal interface. Larvae take 1-2 days longer than wild type to reach the wandering stage. Imaginal discs are missing or rudimentary and larval brains are reduced in size. Endoreplication and polytenization of larval cells is normal, as are salivary gland size and intensity of DNA staining of their polytene nuclei.

(Stern et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Cdk1^E1-9 is a non-suppressor of decreased occurrence of cell division | larval stage phenotype of CycE^JP

(Secombe et al., 1998)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Cdk1^E1-9 is a non-suppressor of eye phenotype of CycE^JP

(Secombe et al., 1998)

Cdk1^E1-9 is a non-suppressor of eye disc posterior to the morphogenetic furrow | larval stage phenotype of CycE^JP

(Secombe et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of cdc2^E1-9 has no effect on the rough eye phenotype or reduction in the number of cells entering S phase posterior to the morphogenetic furrow seen in CycE^JP homozygotes.

(Secombe et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Cdk1^E1-9/Df(2L)J27 is rescued by Cdk1^+t5.8

(Stern et al., 1993)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

S66810

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Cdk1^E1-9

cdc2^E1-9

(Heriche et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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