FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ChATts1
Open Close
General Information
Symbol
Dmel\ChATts1
Species
D. melanogaster
Name
FlyBase ID
FBal0001617
Feature type
allele
Associated gene
Dmel\ChAT
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Chats1/Df(3R)Cha5 flies raised at 18oC and then transferred to 30oC can stand and walk around after 1 day at 30oC. The flies are all paralysed after 3 days at 30oC. Short-latency responses to a single stimulation of the giant fiber are observed in the tergotrochanteral muscle (TTM) but not the dorsal longitudinal muscle (DLM) of Chats1 flies kept at the restrictive temperature.

      (Kitamoto et al., 2000)

      Monoclonal antibodies to CHA recognise a protein of wild-type molecular weight (80kD) but, even at the permissive temperature, in lesser amounts than in the wild-type.

      (Takagawa and Salveterra, 1996)

      Homozygous flies become paralysed and subsequently die at the restrictive temperature. Homozygotes show late embryonic lethality when kept at the restrictive temperature from the beginning of development.

      (Kitamoto and Salvaterra, 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The order for phenotypic severity for temperature-sensitive paralysis in adults is: Chats3 > Chats2 > Chats1.

      (Kitamoto et al., 2000)

      Shows normal GABA staining in stage 17 nerve cord.

      (Kueppers et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      ChATts1
      Chal16
      Chats1
      Chatsl
      (Kitamoto et al., 1992)
      chats1
      (Sadananda et al., 2012, Kitamoto and Salvaterra, 1991)
      choline acetyltransferasets1
      (Kueppers et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (14)