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General Information
Symbol
Dmel\cos5
Species
D. melanogaster
Name
FlyBase ID
FBal0001775
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
cos25
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Lethality occurs in the late embryonic and first larval instar stages. The majority of hemizygotes die as larvae. A few homozygotes survive to late pupal stages and display pattern duplications, sometimes on many body segments. Mutant embryos derived from germ-line clones show an abnormal deletion-duplication phenotype in each segment, similar to that of ptc mutants. The denticle belts are composed on average of five to six denticle rows. The width of the denticle belts is also reduced. A few embryos show an anterior open phenotype.

class I allele cos3 > cos2 > cos1 = cos4 = cos5 > cos6 > cos7

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The maternal effect is almost completely rescued by cos+ in the zygote. Complements the viable cos alleles, unless flies are simultaneously heterozygous for "Cos" mutants.

Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer

Grau & Simpson.

Detected in a screen designed to detect mutations lethal when transheterozygous with cosV1, Pka-C1Cos-3.

Comments
Comments

Allelic series: cos3 >= cos2 >= cos1 = cos4 = cos5 >= cos6 >= cos7.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)