FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cosV5
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General Information
Symbol
Dmel\cosV5
Species
D. melanogaster
Name
FlyBase ID
FBal0001782
Feature type
allele
Associated gene
Dmel\cos
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Grau and Simpson, 1987)
Mutagen
ethyl methanesulfonate
(Grau and Simpson, 1987)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cosV1/cosV5 females show duplication of the dorsal vaginal plate with an increment in the number of sensilla trichodea and loss of the ventral vaginal plate. The eighth tergite and vulva are reduced. Anal plates are abnormal. cosV1/cosV5 males show fusion of the lateral plates and the claspers. The hypandrium phragma is reduced.

      (Sanchez et al., 1997)

      Homozygotes and hemizygotes are viable and morphologically normal.

      (Grau and Simpson, 1987)

      class III allele cosV5 >= cosV4 = cosV1 >= cosV2 >= cosV3

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Pka-C1Cos-2, cosV5/cosV1 has visible phenotype

      (Sanchez-Herrero et al., 1996)
      Phenotype Manifest In
      Other
      Statement
      Reference

      Pka-C1Cos-2, cosV5/cosV1 has leg phenotype

      (Sanchez-Herrero et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Pka-C1Cos-2 cosV1/cosV5 flies have abnormal legs. fuJ; Pka-C1Cos-2 cosV1/cosV5 flies show a cos phenotype in the thorax and legs.

      (Sanchez-Herrero et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Grau & Simpson.

      Comments
      Comments

      Allelic series: cosV5 >= cosV4 = cosV1 >= cosV2 >= cosV3, based on the penetrance of wing duplications.

      (Grau and Simpson, 1987)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      cos-2V5
      (Grau and Simpson, 1987)
      cos2V5
      (Sanchez et al., 1997)
      cosV5
      Name Synonyms
      Secondary FlyBase IDs
        References (3)