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General Information
Symbol
Dmel\Pka-C1Cos-2
Species
D. melanogaster
Name
FlyBase ID
FBal0001784
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Cos12, Cos-12
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G9697179A

Amino acid change:

E130K | Pka-C1-PB; E130K | Pka-C1-PC; E130K | Pka-C1-PD

Reported amino acid change:

E130K

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: E130K.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Class II allele; lethal when homozygous or in heteroallelic combination with other class II alleles.

Local pattern duplications of wing and haltere. Mutant embryos show the same intrasegmental deletion-duplication phenotype typical of cos mutants, and 75% show a disturbed denticle polarity that resembles the paternally rescued cos mutants. A number of embryos fail to differentiate anterior parts. These defects begin at the anterior pole and spread posteriorly.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Pka-C1Cos-2 cosV1/cosV5 flies have abnormal legs. fuJ; Pka-C1Cos-2 cosV1/cosV5 flies show a cos phenotype in the thorax and legs.

cosV1 Pka-C1Cos-2/+ individuals display severe outgrowth of the anterior compartment of the wing disc.

Wings are duplicated when transheterozygous with Df(2R)CA58 (cos-). The phenotype of embryos resulting from crosses involving viable alleles of cos and Pka-C1Cos-2 or Pka-C1Cos-3 indicate a maternal effect on the interaction between Pka-C1 and cos. If the female parent is heterozygous for a viable allele of cos and Pka-C1Cos-2 or Pka-C1Cos-3, and the male parent for Pka-C1Cos-2 or Pka-C1Cos-3, 11% of the embryos show a strong bicaudal phenotype (whereas the reciprocal cross produces less than 1% bicaudal embryos). cosV2, Pka-C1Cos-2/Df(2R)CA58 animals die at various stages of development. The most extreme imaginal phenotypes are observed in those flies that metamorphose but fail to hatch from the pupal case. Pattern duplications can occur on the anterior compartments of all segments of the body, by addition of extra pattern elements, with the possible exception of the clypeolabrum. In the abdomens the smaller anterior bristles are replaced by larger bristles, similar to those that are seen posteriorly, which point anteriorly. The dark pigment is also seen anteriorly. This deletion-duplication phenotype is reminiscent of that seen in cos mutant embryos.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Penetrance and expressivity are variable. The pattern duplications seen in flies heterozygous for neomorphic "Cos" alleles are indistinguishable from those seen in flies homozygous for leaky alleles of cos.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (7)