FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pka-C1Cos-1
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General Information
Symbol
Dmel\Pka-C1Cos-1
Species
D. melanogaster
Name
FlyBase ID
FBal0001783
Feature type
allele
Associated gene
Dmel\Pka-C1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Grau and Simpson, 1987)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Class III allele; homozygous lethal and has no dominant phenotype.

      (Lindsley and Zimm, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      Pka-C1Cos-1, l(2)49Fn[+]/l(2)49Fn1 has wing phenotype

      (Lasko and Pardue, 1988)

      Pka-C1[+]/Pka-C1Cos-1, l(2)49Fn1 has wing phenotype

      (Lasko and Pardue, 1988)

      Df(2R)CA58, Pka-C1Cos-1 has wing phenotype

      (Grau and Simpson, 1987)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      l(2)49Fn1 shows a cupped-wing phenotype when heterozygous with Pka-C1Cos-1.

      (Lasko and Pardue, 1988)

      Wings are duplicated when transheterozygous with Df(2R)CA58 (cos-).

      (Grau and Simpson, 1987)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      R. Whittle.

      (Grau and Simpson, 1987)
      Comments
      Comments

      FBrf0179171 demonstrates that a number of alleles previously assigned to the "Cos" locus actually map to two separate genes; Pka-C1 and Pka-R2. This allele, previously referred to in FlyBase as "Cos1", has been assigned to the Pka-C1 locus because it fails to complement the lethality of Pka-C1Cos-2, Pka-C1Cos-3, Pka-C1Cos-8 and Pka-C1Cos-9 (see FBrf0046012) which were demonstrated in FBrf0179171 to be alleles of Pka-C1.

      (FlyBase, 1992-)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Cos-1W1
      (Grau and Simpson, 1987)
      Cos1W1
      Cos1
      (Lindsley and Zimm, 1992)
      Pka-C1Cos-1
      l(2)cos1
      (Lasko and Pardue, 1988)
      l(2)cos1
      (Whittle, 1976)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)