FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cup1
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General Information
Symbol
Dmel\cup1
Species
D. melanogaster
Name
FlyBase ID
FBal0002146
Feature type
allele
Associated gene
Dmel\cup
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Keyes and Spradling, 1997, Schupbach and Wieschaus, 1991)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      48.5% of eggs laid by heterozygous females have broad single or double dorsal appendages.

      (Neuman-Silberberg, 2007)

      Egg chambers arrest at stage S9-12. Nurse cell nuclear chromatin in the oldest egg chambers appears as five blobs of chromatin, with variable ploidy. Eggs have abnormal karyosomes.

      (Keyes and Spradling, 1997)

      A strong open ended chorion phenotype.

      (Schupbach and Wieschaus, 1991)

      female-sterile in late oogenesis. Follicle cells do not migrate centripetally between nurse cells and oocyte. They do synthesize a chorion which remains open ended (like a chalice, or cup). Such eggs are usually not laid and remain unfertilized. homozygous females show abnormalities

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      cup1 has dorsal appendage phenotype, suppressible | partially by spoon1/spoon[+]

      (Neuman-Silberberg, 2007)
      Suppressor of
      Statement
      Reference

      cup1 is a suppressor of phenotype of nanos18

      (Verrotti and Wharton, 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Only 15.1% of eggs laid by cup1/+ spoon1/+ double heterozygous females have a mutant dorsal appendage phenotype.

      (Neuman-Silberberg, 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      cup1
      (Neuman-Silberberg, 2007, Christensen and Cook, 2006.8.29, Christensen and Cook, 2006.12.5)
      cupWQ52
      (Schupbach and Wieschaus, 1991)
      cupWQ
      Name Synonyms
      Secondary FlyBase IDs
        References (8)