FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cup8
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General Information
Symbol
Dmel\cup8
Species
D. melanogaster
Name
FlyBase ID
FBal0002153
Feature type
allele
Associated gene
Dmel\cup
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Keyes and Spradling, 1997, Schupbach and Wieschaus, 1991)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cupΔ212/cup8 third instar larvae have significant increases in small extra satellite boutons (for example, budding from parent type 1b boutons) at the (muscle 4) neuromuscular junction (NMJ), compared to wild type or heterozygote controls.

      (Menon et al., 2015)

      Egg chambers arrest at stage S5.

      (Keyes and Spradling, 1997)

      Abnormalities in follicle cell migration: open ended chorion.

      (Schupbach and Wieschaus, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      cup8 has ovary phenotype, enhanceable by eIF4E107238/eIF-4E[+]

      (Zappavigna et al., 2004)
      Suppressor of
      Statement
      Reference

      cup[+]/cup8 is a suppressor of egg chamber phenotype of nanos18

      (Verrotti and Wharton, 2000)

      cup[+]/cup8 is a suppressor of ovary phenotype of nanos18

      (Verrotti and Wharton, 2000)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Nup15401501 cup8 double heterozygous females show no obvious defects in egg chamber development.

      (Grimaldi et al., 2007)

      The size of the ovaries in cup8 homozygous adults is reduced by eIF-4E07238/+.

      (Zappavigna et al., 2004)

      The oogenesis defects seen in hemizygous nos18 females are substantially suppressed by one copy of cup8. Many egg chambers in the rescued ovaries appear normal and mature into oocytes that are fertilised and oviposited (the resulting embryos develop no abdominal segments). The rescued females lay eggs for at least 3 weeks.

      (Verrotti and Wharton, 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cup8
      (Saha et al., 2023, Menon et al., 2015)
      cupPN14
      Name Synonyms
      Secondary FlyBase IDs
        References (7)