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General Information
Symbol
Dmel\D4
Species
D. melanogaster
Name
FlyBase ID
FBal0002213
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The aberration breakpoint is -9.8 to -12.4 kb 3' of the D transcription unit (where 0 indicates the translation start site).

Break in D maps to -9.8 to -12.4 where 0 is the translational start of D.

Breaks in 3' D regulatory sequences.

Breakpoint maps 3' to the D transcription unit.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygotes have deletions of anterior and posterior wing structures, including the medial costa, parts of the radius and the alar lobe. The sc25 and sc12 clusters of sensory organs are approximately halved in number and only one or two sc5s remain.

Exhibits a dominant wing hinge phenotype.

Lethal when heterozygous with Dr72 or Dr513. The wing phenotype of the dominant alleles is due to ectopic expression of D in the anlage of the hinge in the wing imaginal disc, as can be reproduced using a DScer\UAS.cSa driven by Scer\GAL430A or Scer\GAL4zfh2-MS209.

Lethal in combination with point alleles of D and small deletions which only remove D sequences.

D4/eyD heterozygotes are viable, unlike dominant late pupal lethal interaction of D1 with eyD. Wings held out at 90o, shorter than wild type and rounder, alulae and adjacent wing tissue is missing, halteres are held down and the presutral bristles are missing.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Sigmund, 1978.

Sigmund, 1978. Craymer, 1978.

Comments
Comments

Shows tissue specific loss of D expression in the embryo.

Shows tissue-specific loss of D expression thus is a regulatory mutation.

Associated with a recessive lethal phenotype that maps to 70D1-2.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
D4
loD4
Name Synonyms
Secondary FlyBase IDs
  • FBal0032089
References (7)