Dr72 SoxNU6-35 double mutant embryos show severe disruption in the organisation and structure of the central nervous system. There is a complete loss of longitudinal axons in many segments and frequent gaps in the neuropil. Commissures are often absent, and those that do form are virtually never separated. The aCC/pCC and CQ neurons are missing in at least 15% of hemisegments. RP2 neurons are missing in 94% of hemisegments and eve lateral cluster neurons are missing in 99% of hemisegments. Neuroblast NB5-3 is missing in 79% of hemisegments.
Scer\GAL4sim.P3.7-mediated expression of Mmus\Sox2Scer\UAS.T:Avic\GFP-EYFP suppresses, whereas expression of Mmus\Sox2ΔHMG.Scer\UAS.T:Avic\GFP-EYFP,T:Hsap\MYC or Mmus\Sox2Scer\UAS.T:Rep-en,T:Hsap\MYC enhances the embryonic CNS defects of Dr72/Df(3L)fz-GS1a animals.