FlyBase Allele Report: Dmel\D[r8]

General Information

Symbol

Dmel\D^r8

Species

D. melanogaster

Name

FlyBase ID

FBal0059165

Feature type

allele

Associated gene

Dmel\D

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Russell et al., 1996)

Progenitor genotype

Caused by aberration

In(3L)D^r8

Cytology

Description

The aberration breakpoint is -5.5 to -6.5 kb 3' of the D transcription unit (where 0 indicates the translation start site).

(Sanchez Soriano and Russell, 2000)

Break in D maps to -5.5 to -6.5 where 0 is the translational start of D.

(Russell, 1999.1.25)

Breakpoint maps 3' to the D transcription unit.

(Russell, 1998.3.2, Russell et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Sanchez Soriano and Russell, 2000, Russell, 1999.1.25, Russell, 1998.3.2, Russell et al., 1996, Carpenter, 1994)

visible | dominant

(Russell, 1999.1.25)

Phenotype Manifest In

abdominal segment

(Russell et al., 1996)

abdominal segment 4

(Russell et al., 1996)

abdominal segment 5

(Russell et al., 1996)

embryonic deutocerebrum

(Sanchez Soriano and Russell, 2000)

embryonic epidermis

(Russell et al., 1996)

embryonic tritocerebrum

(Sanchez Soriano and Russell, 2000)

hindgut

(Sanchez Soriano and Russell, 2000)

wing

(Russell, 1999.1.25)

Detailed Description

Statement

Reference

The nervous system in homozygous embryos appears wild-type apart from defects in the tritocerebrum anlage and subtle defects in the deutocerebrum. The hindgut in these embryos appears normal until stage 13, later the hindgut becomes shorter and its lumen wider compared to wild-type.

(Sanchez Soriano and Russell, 2000)

Lethal when heterozygous with D^r72 or D^r513. The wing phenotype of the dominant alleles is due to ectopic expression of D in the anlage of the hinge in the wing imaginal disc, as can be reproduced using a D^Scer\UAS.cSa driven by Scer\GAL4^30A or Scer\GAL4^zfh2-MS209.

(Russell, 1999.1.25)

No dominant phenotype. Lethal in combination with point alleles of D and small deletions which only remove D sequences.

(Russell, 1998.3.2)

D^r8/Df(3L)D-5rv6 embryos exhibit intermediate segmentation defects showing segment fusions often in A4 and A5. Shows no dominant mutant phenotype.

(Russell et al., 1996)

Lethal when heterozygous with Df(3L)fz-D21, Df(3L)fz-GS1a and Df(3L)D-1rv16 but viable when heterozygous with Df(3L)fz-M21, btl^unspecified and l(3)70Da^unspecified.

(Carpenter, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

D^r8 is a non-enhancer of visible phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

NOT Suppressor of

Statement

Reference

D^r8 is a non-suppressor of visible phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

D^r8 is a non-enhancer of eye phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

NOT Suppressor of

Statement

Reference

D^r8 is a non-suppressor of eye phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

D^r513

(Russell, 1999.1.25)

D^r72

(Russell, 1999.1.25)

D^r513

(Russell, 1998.3.2)

D^r72

(Russell, 1998.3.2)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

4883

y¹ w^*; In(3L)D^r8, mwh¹ D^r8 red¹ e⁴/TM3, ry^RK Sb¹ Ser¹

Kyoto

107927

y¹ w^*; In(3L)D^r8, mwh¹ D^r8 red¹ e⁴/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A.T.C. Carpenter.

(Carpenter, 1994)

Comments

Shows tissue-specific loss of D expression thus is a regulatory mutation.

(Russell, 1999.1.25)

Associated with a recessive lethal phenotype that maps to 70D1-2.

(Russell et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

D^r8

(Aleksic et al., 2013)

loD⁸

(Mukherjee et al., 2006)

Name Synonyms

Secondary FlyBase IDs

FBal0032092

References (8)

Report Sections

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