FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DΔHMG.UAS
Open Close
General Information
Symbol
Dmel\DΔHMG.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0291185
Feature type
allele
Associated gene
Dmel\D
Associated Insertion(s)
Carried in Construct
P{UAS-D.ΔHMG}
Key Links
Transgenic product class
dominant_negative_variant
(Shen et al., 2013)
inframe_deletion
(Shen et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Shen et al., 2013)
inframe_deletion
(Shen et al., 2013)
Mutagen
in vitro construct
(Shen et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-D.ΔHMG}
Cytology
Description

UASt regulates expression of D lacking the HMG DNA-binding domain, that is D amino acids 1-135 fused to amino acids 210-282. This acts as a dominant negative protein.

(Shen et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
D
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4sim.P3.7- or Scer\GAL4pros.C20-mediated expression of DΔHMG.Scer\UAS results in embryos with collapsed commissures, reduced separation between longitudinal tracts, gaps in longitudinal connectives, misrouting and inappropriate midline crossing by longitudinal axons. 50-70% of embryos exhibit some degree of CNS disruption.

      The strong embryonic CNS defects of Dr72/Df(3L)fz-GS1a animals are made worse when DΔHMG.Scer\UASis expressed via Scer\GAL4sim.P3.7 in this background.

      (Shen et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DΔHMG.Scer\UAS
      DΔHMG.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)