FB2026_02 , released June 18, 2026
Allele: Dmel\D6
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General Information
Symbol
Dmel\D6
Species
D. melanogaster
Name
FlyBase ID
FBal0029151
Feature type
allele
Associated gene
Dmel\D
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
(Russell et al., 1996, Carpenter, 1994)
Progenitor genotype
Caused by aberration
In(3LR)D6
Cytology
Description

The aberration breakpoint is -6.5 to -9 kb 3' of the D transcription unit (where 0 indicates the translation start site).

(Sanchez Soriano and Russell, 2000)

Break in D maps to -6.5 to -9 where 0 is the translational start of D.

(Russell, 1999.1.25)

Breaks in 3' D regulatory sequences.

(Russell, 1998.3.2)

Breakpoint maps 3' to the D transcription unit.

(Russell et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Exhibits a dominant wing hinge phenotype. The nervous system in homozygous embryos appears wild-type.

      (Sanchez Soriano and Russell, 2000)

      Lethal when heterozygous with Dr72 or Dr513. The wing phenotype of the dominant alleles is due to ectopic expression of D in the anlage of the hinge in the wing imaginal disc, as can be reproduced using a DScer\UAS.cSa driven by Scer\GAL430A or Scer\GAL4zfh2-MS209.

      (Russell, 1999.1.25)

      Lethal in combination with point alleles of D and small deletions which only remove D sequences.

      (Russell, 1998.3.2)

      Wings are held out at 30o with a slight kink at the axil. Alulae are slightly reduced, both in length and width relative to TM3, which itself has alulae slightly reduced relative to wild type. Halteres are generally in a normal position, presutral bristles are sometimes missing. D phenotype is weak and variable, can overlap wild type especially in young flies. Chromosome also exhibits a dominant kni-like phenotype. Lethal over 70CD deficiencies.

      (Carpenter, 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A.T.C. Carpenter.

      (Carpenter, 1994)
      Comments
      Comments

      Shows tissue specific loss of D expression in the embryo.

      (Russell, 1998.3.2)

      Shows tissue-specific loss of D expression thus is a regulatory mutation.

      (Russell, 1999.1.25)

      Associated with a recessive lethal phenotype that maps to 70D1-2.

      (Russell et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      D6
      Sox70D70
      (Carpenter, 1994)
      loD6
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0032090
      References (9)