FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ddc27
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General Information
Symbol
Dmel\Ddc27
Species
D. melanogaster
Name
FlyBase ID
FBal0002276
Feature type
allele
Associated gene
Dmel\Ddc
Associated Insertion(s)
Carried in Construct
Also Known As
Ddcn27
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
gamma ray
(Gilbert et al., 1984, Wright et al., 1982)
X ray
(Stathakis et al., 1995)
Progenitor genotype
Cytology
Description

2200bp intragenic deletion.

(Stathakis et al., 1995)

2.3kb deletion within Ddc.

(McCrady and Tolin, 1994)

Small deletion within Ddc gene.

(Valles and White, 1990)

2.3kb deletion between coordinates 1.1 and 3.4, DNA that encodes the first two 5' exons and about 500bp of flanking sequences.

(Gilbert et al., 1984)

2kb deletion removing the two 5' exons of Ddc and 0.5kb of 5' flanking DNA.

(Scholnick et al., 1983)

2kb deletion within the limits of the Ddc gene.

(Wright et al., 1982)

2.2kb deletion in Ddc

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant embryos show an abnormal wound healing response after wounding with a sterile micropipette.

      (Mace et al., 2005)

      Heterozygous third instar larvae show a normal response to UVC radiation.

      (Baden et al., 1996)

      When Ddc27/Df(2L)TW130 pharate adult tissue is incubated with dopamine in vitro, wild-type levels of melanisation are obtained.

      (Walter et al., 1996)

      Hemizygous Ddc27/Df(2L)TW130 animals consistently survive to late third larval instar. Ddc27/Df(2L)TW130 ovaries from third instar larvae transplanted into wild-type late third instar larvae develop into normal adult size ovaries which are attached to oviducts or oviduct branches.

      (McCrady and Tolin, 1994)

      As heterozygotes with Ddcts2, at 22oC, flies eclose late and show the incomplete sclerotinization escaper phenotype.

      (Wright et al., 1982)

      Specific DDC activity of newly eclosed adult CyO/Ddc heterozygotes, as percentage of CyO/+ control: 44

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      Ddc27, ple4 has cephalopharyngeal skeleton phenotype

      (Mace et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Ddc27 ; ple4 first instar larvae have almost no melanisation and sclerotisation of the head skeleton.

      (Mace et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer

      Cecil.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (17)